2026-04-29T01:50:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/184032024-11-28T15:32:02Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Boutriq, Soukaina
author
González-González, Alicia
author
Plaza-Andrades, Isaac
author
Laborda-Illanes, Aurora
author
Sánchez-Alcoholado, Lidia
author
Peralta-Linero, Jesús
author
Domínguez-Recio, María Emilia
author
Bermejo-Pérez, María José
author
Lavado-Valenzuela, Rocío
author
Alba, Emilio
author
Queipo-Ortuño, María Isabel
authoraffiliation
[Boutriq,S; González-González,A; Plaza-Andrades,I; Laborda-Illanes,A; Sánchez-Alcoholado,L; Peralta-Linero,J; Domínguez-Recio,ME; Bermejo-Pérez,MJ; Alba;E; Queipo-Ortuño,MI] Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA)-CIMES-UMA, Málaga, Spain. [Boutriq,S; González-González,A; Plaza-Andrades,I; Laborda-Illanes,A; Sánchez-Alcoholado,L; Peralta-Linero,J; Lavado-Valenzuela,R; Queipo-Ortuño,MI] Instituto de Investigación Biomédica de Málaga (IBIMA), Campus de Teatinos s/n, Málaga, Spain. [Boutriq,S; Laborda-Illanes,A; Sánchez-Alcoholado,L] Facultad de Medicina, Universidad de Málaga, Málaga, Spain. [Queipo-Ortuño,MI] Centro de Investigación Biomédica en Red de Cáncer (Ciberonc CB16/12/00481), Madrid, Spain.
2024-02-19T15:29:35Z
2024-02-19T15:29:35Z
2021-07-14
http://hdl.handle.net/10668/3658
http://hdl.handle.net/20.500.12105/18403
34357126
10.3390/jpm11070659
2075-4426
Journal of Personalized Medicine
Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is estrogen-dependent, while Type II appears with non-endometrioid differentiation and follows an estrogen-unrelated pathway. Understanding the molecular biology and genetics of endometrial cancer is crucial for its prognosis and the development of novel therapies for its treatment. However, until now, scant attention has been paid to environmental components like the microbiome. Recently, due to emerging evidence that the uterus is not a sterile cavity, some studies have begun to investigate the composition of the endometrial microbiome and its role in endometrial cancer. In this review, we summarize the current state of this line of investigation, focusing on the relationship between gut and endometrial microbiome and inflammation, estrogen metabolism, and different endometrial cancer therapies.
eng
Endometrial cancer
Endometrial microbiome
Gut microbiome
Dysbiosis
Estrogen metabolism
Estrobolome
Inflammation
Antitumour treatment
Prebiotics
Probiotics
Neoplasias endometriales
Microbioma gastrointestinal
Disbiosis
Inflamación
Prebióticos
Probióticos
Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer
review article