2026-04-29T01:50:42Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/184032024-11-28T15:32:02Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Boutriq, Soukaina author González-González, Alicia author Plaza-Andrades, Isaac author Laborda-Illanes, Aurora author Sánchez-Alcoholado, Lidia author Peralta-Linero, Jesús author Domínguez-Recio, María Emilia author Bermejo-Pérez, María José author Lavado-Valenzuela, Rocío author Alba, Emilio author Queipo-Ortuño, María Isabel author 2021-07-14 Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is estrogen-dependent, while Type II appears with non-endometrioid differentiation and follows an estrogen-unrelated pathway. Understanding the molecular biology and genetics of endometrial cancer is crucial for its prognosis and the development of novel therapies for its treatment. However, until now, scant attention has been paid to environmental components like the microbiome. Recently, due to emerging evidence that the uterus is not a sterile cavity, some studies have begun to investigate the composition of the endometrial microbiome and its role in endometrial cancer. In this review, we summarize the current state of this line of investigation, focusing on the relationship between gut and endometrial microbiome and inflammation, estrogen metabolism, and different endometrial cancer therapies. http://hdl.handle.net/10668/3658 http://hdl.handle.net/20.500.12105/18403 34357126 10.3390/jpm11070659 2075-4426 Journal of Personalized Medicine Endometrial cancer Endometrial microbiome Gut microbiome Dysbiosis Estrogen metabolism Estrobolome Inflammation Antitumour treatment Prebiotics Probiotics Neoplasias endometriales Microbioma gastrointestinal Disbiosis Inflamación Prebióticos Probióticos Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer