2026-08-29T16:26:39Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/184012025-04-30T13:19:58Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Calleja-Conde, Javier author Echeverry-Alzate, Victor author Bühler, Kora-Mareen author Durán-González, Pedro author Morales-García, Jose Ángel author Segovia-Rodríguez, Lucía author Rodríguez de Fonseca, Fernando author Giné, Elena author López-Moreno, José Antonio authoraffiliation [Calleja-Conde,J; Echeverry-Alzate,V; Bühler,KM; Durán-González,P; Segovia-Rodríguez,L; López-Moreno,JA] Departamento de Psicobiología y Metodología en Ciencias del Comportamiento, Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Echeverry-Alzate,V; Rodríguez de Fonseca,F] Unidad Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Malaga University, Málaga, Spain. [Echeverry-Alzate,V] Universidad Nebrija, Campus Madrid-Princesa, 28015 Madrid, Spain. [Morales-García,JÁ] Instituto de Investigaciones Biomédicas (CSIC-UAM) “Alberto Sols” (CSIC-UAM), Madrid, Spain. [Morales-García,JÁ; Giné,E] Departamento de Biología Celular, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. [Morales-García,JÁ] Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. 2024-02-19T15:29:34Z 2024-02-19T15:29:34Z 2021-07-13 10.3390/ijms22147485 1422-0067 International Journal of Molecular Sciences http://hdl.handle.net/10668/3751 34299105 http://hdl.handle.net/20.500.12105/18401 The human gut is the largest organ with immune function in our body, responsible for regulating the homeostasis of the intestinal barrier. A diverse, complex and dynamic population of microorganisms, called microbiota, which exert a significant impact on the host during homeostasis and disease, supports this role. In fact, intestinal bacteria maintain immune and metabolic homeostasis, protecting our organism against pathogens. The development of numerous inflammatory disorders and infections has been linked to altered gut bacterial composition or dysbiosis. Multiple factors contribute to the establishment of the human gut microbiota. For instance, diet is considered as one of the many drivers in shaping the gut microbiota across the lifetime. By contrast, alcohol is one of the many factors that disrupt the proper functioning of the gut, leading to a disruption of the intestinal barrier integrity that increases the permeability of the mucosa, with the final result of a disrupted mucosal immunity. This damage to the permeability of the intestinal membrane allows bacteria and their components to enter the blood tissue, reaching other organs such as the liver or the brain. Although chronic heavy drinking has harmful effects on the immune system cells at the systemic level, this review focuses on the effect produced on gut, brain and liver, because of their significance in the link between alcohol consumption, gut microbiota and the immune system. eng Alcohol Gut Microbiota Brain Liver Immune system Dysbiosis Microbioma gastrointestinal Encéfalo HígadoSistema inmunológico Sistema inmunológico Disbiosis The Immune System through the Lens of Alcohol Intake and Gut Microbiota review article