2026-04-29T06:16:09Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/183932024-09-21T20:00:01Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16971
Repisalud author Galván, Sandra Torres author Flores-López, María author Romero-Sanchiz, Pablo author Requena-Ocaña, Nerea author Porras-Perales, Oscar author Nogueira-Arjona, Raquel author Mayoral, Fermín author Araos, Pedro author Serrano, Antonia author Muga, Roberto author Pavón, Francisco Javier author García-Marchena, Nuria author de Fonseca, Fernando Rodríguez 2024-02-19T15:29:26Z 2024-02-19T15:29:26Z 2021-07-01 http://hdl.handle.net/10668/18139 http://hdl.handle.net/20.500.12105/18393 34211033 10.1038/s41598-021-93075-1 2045-2322 Scientific reports Granulocyte colony-stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = - 0.233, p  eng Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder. research article