2026-04-29T16:56:08Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/183892024-09-21T20:12:07Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Bonora, Enzo author Frias, Juan P author Tinahones, Francisco J author Van, Joanna author Malik, Raleigh E author Yu, Zhuoxin author Mody, Reema author Bethel, Angelyn author Kwan, Anita Y M author Cox, David A 2024-02-19T15:29:23Z 2024-02-19T15:29:23Z 2021-06-29 10.1111/dom.14465 1463-1326 Diabetes, obesity & metabolism http://hdl.handle.net/10668/18058 34189841 http://hdl.handle.net/20.500.12105/18389 To evaluate the impact of dulaglutide 3.0 and 4.5 mg versus 1.5 mg on body weight in patients with type 2 diabetes (T2D) based on exploratory analyses of the AWARD-11 trial. Patients were randomized to once-weekly dulaglutide 1.5 (n = 612), 3.0 (n = 616) or 4.5 mg (n = 614) for 52 weeks. The primary objective was superiority of dulaglutide 3.0 and/or 4.5 mg over 1.5 mg in HbA1c reduction at 36 weeks. Secondary and exploratory assessments included weight reduction in the overall trial population and baseline body mass index (BMI) and HbA1c subgroups. At baseline, patients had a mean age of 57.1 years, HbA1c 8.6% (70 mmol/mol), weight 95.7 kg and BMI 34.2 kg/m2 . At 36 weeks, dulaglutide 3.0 and 4.5 mg were superior to 1.5 mg for weight change from baseline (1.5 mg, -3.1 kg; 3.0 mg, -4.0 kg [P = .001]; 4.5 mg, -4.7 kg [P  In patients with T2D, inadequately controlled by metformin, incremental weight loss was observed with dulaglutide 1.5, 3.0 and 4.5 mg doses regardless of baseline BMI or HbA1c. Although absolute weight loss was numerically greater in patients with higher baseline BMI, percentage of weight loss was similar between BMI subgroups. eng dulaglutide type 2 diabetes weight Effect of dulaglutide 3.0 and 4.5 mg on weight in patients with type 2 diabetes: Exploratory analyses of AWARD-11. research article