2026-08-29T07:32:04Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/183872024-02-19T15:29:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Laborda-Illanes, Aurora author Sánchez-Alcoholado, Lidia author Boutriq, Soukaina author Plaza-Andrades, Isaac author Peralta-Linero, Jesús author Alba, Emilio author González-González, Alicia author Queipo-Ortuño, María Isabel 2024-02-19T15:29:21Z 2024-02-19T15:29:21Z 2021-06-23 10.3390/cancers13133141 2072-6694 Cancers http://hdl.handle.net/10668/18087 34201776 http://hdl.handle.net/20.500.12105/18387 In this review we summarize a possible connection between gut microbiota, melatonin production, and breast cancer. An imbalance in gut bacterial population composition (dysbiosis), or changes in the production of melatonin (circadian disruption) alters estrogen levels. On the one hand, this may be due to the bacterial composition of estrobolome, since bacteria with β-glucuronidase activity favour estrogens in a deconjugated state, which may ultimately lead to pathologies, including breast cancer. On the other hand, it has been shown that these changes in intestinal microbiota stimulate the kynurenine pathway, moving tryptophan away from the melatonergic pathway, thereby reducing circulating melatonin levels. Due to the fact that melatonin has antiestrogenic properties, it affects active and inactive estrogen levels. These changes increase the risk of developing breast cancer. Additionally, melatonin stimulates the differentiation of preadipocytes into adipocytes, which have low estrogen levels due to the fact that adipocytes do not express aromatase. Consequently, melatonin also reduces the risk of breast cancer. However, more studies are needed to determine the relationship between microbiota, melatonin, and breast cancer, in addition to clinical trials to confirm the sensitizing effects of melatonin to chemotherapy and radiotherapy, and its ability to ameliorate or prevent the side effects of these therapies. eng anticancer therapies breast cancer circadian disruption dysbiosis estrobolome estrogens gut microbiota melatonin short-chain fatty acids tryptophan metabolism A New Paradigm in the Relationship between Melatonin and Breast Cancer: Gut Microbiota Identified as a Potential Regulatory Agent. research article