2026-04-29T04:10:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183832024-11-28T14:59:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Nieto-Quero, Andrea
author
Chaves-Peña, Patricia
author
Santín, Luis J.
author
Pérez-Martín, Margarita
author
Pedraza, Carmen
authoraffiliation
[Nieto-Quero,A; Chaves-Peña,P; Santín,LJ; Pedraza,C] Departamento de Psicobiología y Metodología en las CC, Universidad de Málaga, Málaga, Spain. [Chaves-Peña,P; Pérez-Martín,M] Departamento de Biología Celular, Genética y Fisiología, Universidad de Málaga, Málaga, Spain. [Nieto-Quero,A; Santín,LJ; Pérez-Martín,M; Pedraza,C] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
2024-02-19T15:29:18Z
2024-02-19T15:29:18Z
2021-06-18
http://hdl.handle.net/10668/3640
http://hdl.handle.net/20.500.12105/18383
34355047
10.1016/j.ynstr.2021.100356
2352-2895
Neurobiology of Stress
Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The hippocampus is a target structure of the adverse effects of stress, and hippocampal neurogenesis plays a crucial role. However, we do not know the mechanisms by which stress impacts neurogenesis. Recent studies indicate that changes in neuroinflammation, primarily via microglial cells, may play an essential role in this process. However, the relationship between stress, microglial changes, and alterations in neurogenesis and their involvement in the development of depression is poorly characterized. For this reason, this systematic review aims to synthesise and evaluate current studies that have investigated the relationship between these variables. Taken together, the revised data, although not entirely conclusive, seem to suggest that microglial changes induced by psychological stress regulate neurogenesis and in turn may be responsible for the development of depressive-like behaviours, but other factors that influence these stressful experiences should not be dismissed.
eng
Psychosocial stress
Neurogenesis
Microglia
Neuroinflammation
Depression
Animal models
Systematic review
Neurogénesis
Modelos animales
Microglía
Neurogénesis
Depresión
Modelos animales
Revisión sistemática
Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
research article