2026-04-29T02:37:57Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/183832024-11-28T14:59:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Nieto-Quero, Andrea author Chaves-Peña, Patricia author Santín, Luis J. author Pérez-Martín, Margarita author Pedraza, Carmen author 2021-06-18 Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The hippocampus is a target structure of the adverse effects of stress, and hippocampal neurogenesis plays a crucial role. However, we do not know the mechanisms by which stress impacts neurogenesis. Recent studies indicate that changes in neuroinflammation, primarily via microglial cells, may play an essential role in this process. However, the relationship between stress, microglial changes, and alterations in neurogenesis and their involvement in the development of depression is poorly characterized. For this reason, this systematic review aims to synthesise and evaluate current studies that have investigated the relationship between these variables. Taken together, the revised data, although not entirely conclusive, seem to suggest that microglial changes induced by psychological stress regulate neurogenesis and in turn may be responsible for the development of depressive-like behaviours, but other factors that influence these stressful experiences should not be dismissed. http://hdl.handle.net/10668/3640 http://hdl.handle.net/20.500.12105/18383 34355047 10.1016/j.ynstr.2021.100356 2352-2895 Neurobiology of Stress Psychosocial stress Neurogenesis Microglia Neuroinflammation Depression Animal models Systematic review Neurogénesis Modelos animales Microglía Neurogénesis Depresión Modelos animales Revisión sistemática Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models