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00925njm 22002777a 4500 dc Roy-Vallejo, Emilia author Sánchez Purificación, Aquilino author Torres Peña, José David author Sánchez Moreno, Beatriz author Arnalich, Francisco author García Blanco, María José author López Miranda, José author Romero-Cabrera, Juan Luis author Herrero Gil, Carmen Rosario author Bascunana, José author Rubio-Rivas, Manuel author Pintos Otero, Sara author Martínez Sempere, Verónica author Ballano Rodríguez-Solís, Jesús author Gil Sánchez, Ricardo author Luque Del Pino, Jairo author González Noya, Amara author Navas-Alcántara, María Sierra author Cortés Rodríguez, Begoña author Alcalá, José Nicolás author Suárez-Lombraña, Ana author Andrés Soler, Jorge author Gómez-Huelgas, Ricardo author Casas-Rojo, José Manuel author Millán Núñez-Cortés, Jesús author On Behalf Of The Semi-Covid-Network, author 2021-06-15 Our main aim was to describe the effect on the severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter study evaluating hospitalized patients with COVID-19 treated with ACEI/ARB. The primary endpoint was the incidence of the composite outcome of prognosis (IMV (invasive mechanical ventilation), NIMV (non-invasive mechanical ventilation), ICU admission (intensive care unit), and/or all-cause mortality). We evaluated both outcomes in patients whose treatment with ACEI/ARB was continued or withdrawn. Between February and June 2020, 11,205 patients were included, mean age 67 years (SD = 16.3) and 43.1% female; 2162 patients received ACEI/ARB treatment. ACEI/ARB treatment showed lower all-cause mortality (p 10.3390/jcm10122642 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/18098 34204014 http://hdl.handle.net/20.500.12105/18379 ACEI ARB COVID-19 MACE prognosis Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19.