2026-07-23T23:02:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183752024-11-28T15:41:30Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16980
Repisalud
author
Tovar, Rubén
author
Vargas, Antonio
author
Aranda, Jesús
author
Sánchez-Salido, Lourdes
author
González-González, Laura
author
Chowen, Julie A.
author
Rodríguez de Fonseca, Fernando
author
Suárez, Juan
author
Rivera, Patricia
authoraffiliation
[Tovar,R; Vargas,A; Aranda,J; Sánchez-Salido,L; González-González,L; Rodríguez de Fonseca,F; Suárez,J; Rivera,P] Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Tovar,R; Vargas,A; Sánchez-Salido,L; Rodríguez de Fonseca,F; Rivera,P] UGC Salud Mental, Hospital Regional Universitario de Málaga, Málaga, Spain. [Tovar,R; Aranda,J] Andalucia Tech, Facultad de Medicina, Universidad de Málaga, Málaga, Spain. [Chowen,JA] Department of Endocrinology, Instituto de Investigación Biomédica la Princesa, Fundación Investigación Biomédica del Hospital Infantil Universitario Niño Jesús, Madrid, Spain. [Chowen,JA] CIBEROBN (Centro de Investigación Biomédica en Red Sobre Fisiopatología de la Obesidad y Nutrición), Instituto de Salud Carlos III, Madrid, Spain. [Chowen,JA] IMDEA Food Institute, CEI UAM + CSIC, Madrid, Spain. [Suárez,J] Departamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia, Universidad de Málaga, Málaga, Spain.
2024-02-19T15:29:12Z
2024-02-19T15:29:12Z
2021-06-11
10.3390/ijms22126292
1422-0067
International Journal of Molecular Sciences
http://hdl.handle.net/10668/3956
34208173
http://hdl.handle.net/20.500.12105/18375
Maternal malnutrition in critical periods of development increases the risk of developing short- and long-term diseases in the offspring. The alterations induced by this nutritional programming in the hypothalamus of the offspring are of special relevance due to its role in energy homeostasis, especially in the endocannabinoid system (ECS), which is involved in metabolic functions. Since astrocytes are essential for neuronal energy efficiency and are implicated in brain endocannabinoid signaling, here we have used a rat model to investigate whether a moderate caloric restriction (R) spanning from two weeks prior to the start of gestation to its end induced changes in offspring hypothalamic (a) ECS, (b) lipid metabolism (LM) and/or (c) hypothalamic astrocytes. Monitorization was performed by analyzing both the gene and protein expression of proteins involved in LM and ECS signaling. Offspring born from caloric-restricted mothers presented hypothalamic alterations in both the main enzymes involved in LM and endocannabinoids synthesis/degradation. Furthermore, most of these changes were similar to those observed in hypothalamic offspring astrocytes in culture. In conclusion, a maternal low caloric intake altered LM and ECS in both the hypothalamus and its astrocytes, pointing to these glial cells as responsible for a large part of the alterations seen in the total hypothalamus and suggesting a high degree of involvement of astrocytes in nutritional programming.
eng
Perinatal programming
Hypothalamus
Astrocytes
Endocannabinoid system
Lipid metabolism
Atención perinatal
Hipotálamo
Astrocitos
Endocannabinoides
Metabolismo de los lípidos
Analysis of Both Lipid Metabolism and Endocannabinoid Signaling Reveals a New Role for Hypothalamic Astrocytes in Maternal Caloric Restriction-Induced Perinatal Programming
research article