2026-07-23T23:02:10Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/183752024-11-28T15:41:30Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16980

00925njm 22002777a 4500 dc Tovar, Rubén author Vargas, Antonio author Aranda, Jesús author Sánchez-Salido, Lourdes author González-González, Laura author Chowen, Julie A. author Rodríguez de Fonseca, Fernando author Suárez, Juan author Rivera, Patricia author 2021-06-11 Maternal malnutrition in critical periods of development increases the risk of developing short- and long-term diseases in the offspring. The alterations induced by this nutritional programming in the hypothalamus of the offspring are of special relevance due to its role in energy homeostasis, especially in the endocannabinoid system (ECS), which is involved in metabolic functions. Since astrocytes are essential for neuronal energy efficiency and are implicated in brain endocannabinoid signaling, here we have used a rat model to investigate whether a moderate caloric restriction (R) spanning from two weeks prior to the start of gestation to its end induced changes in offspring hypothalamic (a) ECS, (b) lipid metabolism (LM) and/or (c) hypothalamic astrocytes. Monitorization was performed by analyzing both the gene and protein expression of proteins involved in LM and ECS signaling. Offspring born from caloric-restricted mothers presented hypothalamic alterations in both the main enzymes involved in LM and endocannabinoids synthesis/degradation. Furthermore, most of these changes were similar to those observed in hypothalamic offspring astrocytes in culture. In conclusion, a maternal low caloric intake altered LM and ECS in both the hypothalamus and its astrocytes, pointing to these glial cells as responsible for a large part of the alterations seen in the total hypothalamus and suggesting a high degree of involvement of astrocytes in nutritional programming. 10.3390/ijms22126292 1422-0067 International Journal of Molecular Sciences http://hdl.handle.net/10668/3956 34208173 http://hdl.handle.net/20.500.12105/18375 Perinatal programming Hypothalamus Astrocytes Endocannabinoid system Lipid metabolism Atención perinatal Hipotálamo Astrocitos Endocannabinoides Metabolismo de los lípidos Analysis of Both Lipid Metabolism and Endocannabinoid Signaling Reveals a New Role for Hypothalamic Astrocytes in Maternal Caloric Restriction-Induced Perinatal Programming