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oai:repisalud.isciii.es:20.500.12105/183742024-11-28T14:49:26Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Lillo, Eugenia author Gutierrez-Cardo, Antonio author Murcia-Casas, Belén author Carrillo-Linares, Juan Luis author Garcia-Argüello, Francisco author Chicharo de Freitas, Reinaldo author Baquero-Aranda, Isabel author Valdivielso, Pedro author García-Fernández, María author Sánchez-Chaparro, Miguel Ángel authoraffiliation [Lillo,E; Garcia-Argüello,F; Chicharo de Freitas,R] Molecular Imaging Unit, Centro de Investigaciones Médico Sanitarias (CIMES), Fundación General de la Universidad de Málaga, Málaga, Spain. [Gutierrez-Cardo,A] Nuclear Medicine Department, Regional Hospital, Malaga, Spain. [Gutierrez-Cardo,A; Carrillo-Linares,JL; Garcia-Argüello,F; Valdivielso,P; García-Fernández,M; Sánchez-Chaparro,MÁ] Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain. [Murcia-Casas,B; Carrillo-Linares,JL; Valdivielso,P; Sánchez-Chaparro,MÁ] Internal Medicine Unit, Virgen de la Victoria Hospital, Malaga, Spain. [Baquero-Aranda,I] Ophtalmology Unit, Virgen de la Victoria Hospital, Malaga, Spain. [Valdivielso,P; Sánchez-Chaparro,MÁ] Department of Medicine and Dermatology, University of Malaga, Malaga, Spain. [García-Fernández,M] Department of Human Physiology, University of Malaga, Malaga, Spain. 2024-02-19T15:29:11Z 2024-02-19T15:29:11Z 2021-06-11 10.3390/jcm10122588 2077-0383 Journal of Clinical Medicine http://hdl.handle.net/10668/4491 34208205 http://hdl.handle.net/20.500.12105/18374 Active microcalcification of elastic fibers is a hallmark of pseudoxanthoma elasticum and it can be measured with the assessment of deposition of 18F-NaF using a PET/CT scan at the skin and vascular levels. It is not known whether this deposition changes over time in absence of specific therapy. We repeated in two years a PET/CT scan using 18F-NaF as a radiopharmaceutical in patients with the disease and compared the deposition at skin and vessel. Furthermore, calcium score values at the vessel wall were also assessed. Main results indicate in the vessel walls that calcification progressed in each patient; by contrast, the active microcalcification, measured and target-to-background ratio showed reduced active deposition. By contrast, at skin levels (neck and axillae) the uptake of the pharmaceutical remains unchanged. In conclusion, because calcification in the arterial wall is not specific for pseudoxanthoma elasticum condition, the measurement of the deposition of 18F-NaF in the neck might be potentially used as a surrogate marker in future trials for the disease. eng Pseudoxanthoma elasticum Inorganic pyrophosphate Microcalcification 18F-NaF PET/CT Seudoxantoma elástico Pirofosfatasa inorgánica Calcinosis Fluoruro de sodio Tomografía computarizada por tomografía de emisión de positrones Tejido elástico Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum research article