2026-04-29T12:24:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183732024-11-28T15:17:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Guillot-Sestier, Marie-Victoire
author
Araiz, Ana Rubio
author
Mela, Virginia
author
Gaban, Aline Sayd
author
O'Neill, Eoin
author
Joshi, Lisha
author
Chouchani, Edward T.
author
Mills, Evanna L.
author
Lynch, Marina A.
authoraffiliation
[Guillot-Sestier,MV; Araiz,AR; Mela,V; Gaban,AS; O'Neill,E; Lynch,MA] Trinity College Institute for Neuroscience, Trinity College, Dublin 2, Ireland. [Joshi,L] Gottfried Schatz Research Centre, Medical University of Graz, Graz, Austria. [Chouchani,ET; Mills,EL] Department of Cancer Biology, Dana–Farber Cancer Institute, Boston, MA, USA. [Chouchani,ET; Mills,EL] Department of Cell Biology, Harvard Medical School, Boston, MA, USA. [Mela,V] Department of Endocrinology and Nutrition, Instituto de Investigación Biomédica de Malaga (IBIMA), Virgen de la Victoria University Hospital, Málaga University, Malaga, Spain.
2024-02-19T15:29:10Z
2024-02-19T15:29:10Z
2021-06-10
10.1038/s42003-021-02259-y
2399-3642
Communications Biology
http://hdl.handle.net/10668/4035
34112929
http://hdl.handle.net/20.500.12105/18373
Age and sex are major risk factors in Alzheimer's disease (AD) with a higher incidence of the disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease pathogenesis and is inexorably linked with inappropriate microglial activation and neurodegeneration. We investigated sex-related differences in microglia in APP/PS1 mice and in post-mortem tissue from AD patients. Changes in genes that are indicative of microglial activation were preferentially increased in cells from female APP/PS1 mice and cells from males and females were morphological, metabolically and functionally distinct. Microglia from female APP/PS1 mice were glycolytic and less phagocytic and associated with increased amyloidosis whereas microglia from males were amoeboid and this was also the case in post-mortem tissue from male AD patients, where plaque load was reduced. We propose that the sex-related differences in microglia are likely to explain, at least in part, the sexual dimorphism in AD.
eng
Microglial metabolism
Sexual dimorphism
Alzheimer’s disease
Risk factors
Amyloidosis
Genes
Microglía
Metabolismo
Características sexuales
Enfermedad de Alzheimer
Factores de riesgo
Amiloidosis
Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease
research article