2026-08-29T14:55:20Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183652025-05-05T13:01:01Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16982
Repisalud
author
Ruiz-Limon, Patricia
author
Ladehesa-Pineda, Maria L.
author
Lopez-Medina, Clementina
author
López-Pedrera, Chary
author
Abalos-Aguilera, Maria C.
author
Barbarroja, Nuria
author
Arias-Quiros, Isabel
author
Perez-Sanchez, Carlos
author
Arias-de la Rosa, Ivan
author
Ortega-Castro, Rafaela
author
Escudero-Contreras, Alejandro
author
Collantes-Estevez, Eduardo
author
Jimenez-Gomez, Yolanda
authoraffiliation
[Ruiz-Limon,P; Ladehesa-Pineda,ML; Lopez-Medina,C; Lopez-Pedrera,C; Abalos-Aguilera,MC; Barbarroja,N; Arias-Quiros,I; Perez-Sanchez,C; Arias-de la Rosa,I; Ortega-Castro,R; Escudero-Contreras,A; Collantes-Estevez,E; Jimenez-Gomez,Y] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain. [Ruiz-Limon,P; Ladehesa-Pineda,ML; Lopez-Pedrera,C; Abalos-Aguilera,MC; Barbarroja,N; Arias-Quiros,I; Perez-Sanchez,C; Arias-de la Rosa,I; Ortega-Castro,R; Escudero-Contreras,A; Collantes-Estevez,E; Jimenez-Gomez,Y] UGC Rheumatology, Reina Sofia University Hospital, Córdoba, Spain. [Ruiz-Limon,P; Ladehesa-Pineda,ML; Lopez-Medina,C; Lopez-Pedrera,C; Abalos-Aguilera,MC; Barbarroja,N; Arias-Quiros,I; Perez-Sanchez,C; Arias-de la Rosa,I; Ortega-Castro,R; Escudero-Contreras,A; Collantes-Estevez,E; Jimenez-Gomez,Y] Department of Medicine (Medicine, Dermatology and Otorhinolaryngology), University of Córdoba, Córdoba, Spain. [Ruiz-Limon,P] UGC of Endocrinology and Nutrition, The Biomedical Research Institute of Málaga (IBIMA), Virgen de la Victoria Hospital, Málaga, Spain. [Ruiz-Limon,P] CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain.
2024-02-19T15:28:37Z
2024-02-19T15:28:37Z
2021-06-04
10.3390/diagnostics11061037
2075-4418
Diagnostics
http://hdl.handle.net/10668/4219
34199950
http://hdl.handle.net/20.500.12105/18365
Endothelial dysfunction (ED) is well known as a process that can lead to atherosclerosis and is frequently presented in radiographic axial spondyloarthritis (r-axSpA) patients. Here, we investigated cellular and molecular mechanisms underlying r-axSpA-related ED, and analyzed the potential effect of peripheral blood mononuclear cells (PBMCs) in promoting endothelial injury in r-axSpA. A total of 30 r-axSpA patients and 32 healthy donors (HDs) were evaluated. The endothelial function, inflammatory and atherogenic profile, and oxidative stress were quantified. In vitro studies were designed to evaluate the effect of PBMCs from r-axSpA patients on aberrant endothelial activation. Compared to HDs, our study found that, associated with ED and the plasma proatherogenic profile present in r-axSpA, PBMCs from these patients displayed a pro-oxidative, proinflammatory, and proatherogenic phenotype, with most molecular changes noticed in lymphocytes. Correlation studies revealed the relationship between this phenotype and the microvascular function. Additional in vitro studies confirmed that PBMCs from r-axSpA patients promoted endothelial injury. Altogether, this study suggests the relevance of r-axSpA itself as a strong and independent cardiovascular risk factor, contributing to a dysfunctional endothelium and atherogenic status by aberrant activation of PBMCs. Lymphocytes could be the main contributors in the development of ED and subsequent atherosclerosis in this pathology.
eng
Endothelium
Circulating mononuclear cells
Inflammation
Oxidative stress
Radiographic axial spondyloarthritis
Endotelio
Leucocitos mononucleares
Inflamación
Estrés oxidativo
Espondiloartrite axial
Potential Role and Impact of Peripheral Blood Mononuclear Cells in Radiographic Axial Spondyloarthritis-Associated Endothelial Dysfunction
research article