2026-08-29T14:55:39Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/183652025-05-05T13:01:01Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16982

00925njm 22002777a 4500 dc Ruiz-Limon, Patricia author Ladehesa-Pineda, Maria L. author Lopez-Medina, Clementina author López-Pedrera, Chary author Abalos-Aguilera, Maria C. author Barbarroja, Nuria author Arias-Quiros, Isabel author Perez-Sanchez, Carlos author Arias-de la Rosa, Ivan author Ortega-Castro, Rafaela author Escudero-Contreras, Alejandro author Collantes-Estevez, Eduardo author Jimenez-Gomez, Yolanda author 2021-06-04 Endothelial dysfunction (ED) is well known as a process that can lead to atherosclerosis and is frequently presented in radiographic axial spondyloarthritis (r-axSpA) patients. Here, we investigated cellular and molecular mechanisms underlying r-axSpA-related ED, and analyzed the potential effect of peripheral blood mononuclear cells (PBMCs) in promoting endothelial injury in r-axSpA. A total of 30 r-axSpA patients and 32 healthy donors (HDs) were evaluated. The endothelial function, inflammatory and atherogenic profile, and oxidative stress were quantified. In vitro studies were designed to evaluate the effect of PBMCs from r-axSpA patients on aberrant endothelial activation. Compared to HDs, our study found that, associated with ED and the plasma proatherogenic profile present in r-axSpA, PBMCs from these patients displayed a pro-oxidative, proinflammatory, and proatherogenic phenotype, with most molecular changes noticed in lymphocytes. Correlation studies revealed the relationship between this phenotype and the microvascular function. Additional in vitro studies confirmed that PBMCs from r-axSpA patients promoted endothelial injury. Altogether, this study suggests the relevance of r-axSpA itself as a strong and independent cardiovascular risk factor, contributing to a dysfunctional endothelium and atherogenic status by aberrant activation of PBMCs. Lymphocytes could be the main contributors in the development of ED and subsequent atherosclerosis in this pathology. 10.3390/diagnostics11061037 2075-4418 Diagnostics http://hdl.handle.net/10668/4219 34199950 http://hdl.handle.net/20.500.12105/18365 Endothelium Circulating mononuclear cells Inflammation Oxidative stress Radiographic axial spondyloarthritis Endotelio Leucocitos mononucleares Inflamación Estrés oxidativo Espondiloartrite axial Potential Role and Impact of Peripheral Blood Mononuclear Cells in Radiographic Axial Spondyloarthritis-Associated Endothelial Dysfunction