2026-08-29T14:17:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183622024-11-28T15:00:12Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16971col_20.500.12105_16977
Repisalud
author
Franco, Fernando
author
Carcereny, Enric
author
Guirado, Maria
author
Ortega, Ana L.
author
López-Castro, Rafael
author
Rodríguez-Abreu, Delvys
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García-Campelo, Rosario
author
Del Barco, Edel
author
Juan, Oscar
author
Aparisi, Francisco
author
González-Larriba, Jose L.
author
Domine, Manuel
author
Trigo, Jose M.
author
Cobo, Manuel
author
Cerezo, Sara
author
Calzas, Julia
author
Massutí, Bartomeu
author
Bosch-Barrera, Joaquim
author
García Coves, Paola
author
Domènech, Marta
author
Provencio, Mariano
authoraffiliation
[Franco,F; Provencio,M] Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain. [Carcereny,E; Domènech,M] Catalan Institute of Oncology, Hospital Universitari Germans Trias i Pujol, B-ARGO, IGTP, Badalona, Spain. [Guirado,M; García Coves,P] Hospital General Universitario de Elche, Elche, Spain. [Ortega,AL] Hospital Universitario de Jaén, Jaén, Spain. [López-Castro,R] Hospital Clínico Universitario de Valladolid, Valladolid, Spain. [Rodríguez-Abreu,D] Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain. [García-Campelo,R] Complejo Hospitalario Universitario A Coruña, A Coruña, Spain. [Del Barco,E] Hospital Universitario de Salamanca, Salamanca, Spain. [Juan,O] Hospital Universitario y Politécnico La Fe, Valencia, Spain. [Aparisi,F] Hospital General de Valencia, Valencia, Spain. [González-Larriba,JL] Hospital Universitario Clínico San Carlos, Madrid, Spain. [Domine,M] Hospital Universitario Fundación Jiménez Díaz, IIS-FJD, Madrid, Spain. [Trigo,JM; Cobo,M] Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, IBIMA, Málaga, Spain. [Cerezo,S] Hospital General La Mancha Centro, Alcázar de San Juan, Spain. [Calzas,J] Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain. [Massutí,B] Hospital General Universitario de Alicante, Alicante, Spain. [Bosch-Barrera,J] Catalan Institute of Oncology, Girona, Spain.
2024-02-19T15:28:33Z
2024-02-19T15:28:33Z
2021-06-02
10.1371/journal.pone.0251761
1932-6203
PLOS ONE
http://hdl.handle.net/10668/4053
34077442
http://hdl.handle.net/20.500.12105/18362
Background Small-cell lung cancer (SCLC) is an aggressive disease with high metastatic potential and poor prognosis. Due to its low prevalence, epidemiological and clinical information of SCLC patients retrieved from lung cancer registries is scarce. Patients and methods This was an observational multicenter study that enrolled patients with lung cancer and tho racic tumors, recruited from August 2016 to January 2020 at 50 Spanish hospitals. Demo graphic and clinical data, treatment patterns and survival of SCLC patients included in the Thoracic Tumor Registry (TTR) were analyzed. Results With a total of 956 cases, the age of 64.7 ± 9.1 years, 78.6% were men, 60.6% smokers, and ECOG PS 0, 1 or 2 in 23.1%, 53.0% and 23.8% of cases, respectively. Twenty per cent of patients had brain metastases at the diagnosis. First-line chemotherapy (CT), mainly carboplatin or cisplatin plus etoposide was administered to >90% of patients. In total, 36.0% and 13.8% of patients received a second and third line of CT, respectively. Median overallsurvival was 9.5 months (95% CI 8.8–10.2 months), with an estimated rate of 70.3% (95% CI 67.2–73.4%), 38.9% (95% CI 35.4–42.4%), and 14.8% (95% CI 11.8–17.8%) at 6, 12 and 24 months respectively. Median progression-free survival was 6.3 months. Higher mor tality and progression rates were significantly associated with male sex, older age, smoking habit, and ECOG PS 1–2. Long-term survival (> 2 years) was confirmed in 6.6% of patients,showing a positive correlation with better ECOG PS, poor smoking and absence of certain metastases at diagnosis. Conclusion This study provides an updated overview of the clinical situation and treatment landscape of ES-SCLC in Spain. Our results might assist oncologists to improve current clinical practice towards a better prognosis for these patients.
eng
Epidemiology
Treatment
Survival
Small cell lung cancer
Spain
Thoracic tumor
Epidemiología
Terapéutica
Supervivencia (salud pública)
Carcinoma pulmonar de células pequeñas
España
Neoplasias torácicas
Epidemiology, treatment, and survival in small cell lung cancer in Spain: Data from the Thoracic Tumor Registry
research article