2026-06-14T02:27:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183562024-11-28T14:48:42Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Perez-Tejeiro, Jose Miguel
author
Csukasi, Fabiana
authoraffiliation
[Perez-Tejeiro,JM; Csukasi,F] Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, IBIMA, University of Málaga, Málaga, Spain. [Perez-Tejeiro,JM; Csukasi,F] Biomaterials and Nanomedicine (CIBER-BBN), Andalusian Centre for Nanomedicine and Biotechnology-BIONAND, Networking Biomedical Research Center in Bioengineering, Málaga, Spain.
2024-02-19T15:28:29Z
2024-02-19T15:28:29Z
2021-05-27
10.3389/fgene.2021.667283
1664-8021
Frontiers in Genetics
http://hdl.handle.net/10668/4091
34122519
http://hdl.handle.net/20.500.12105/18356
Discovered in 2009, the DEP-domain containing mTOR-interacting protein, DEPTOR, is a known regulator of the mechanistic target of rapamycin (mTOR), an evolutionarily conserved kinase that regulates diverse cellular processes in response to environmental stimuli. DEPTOR was originally identified as a negative regulator of mTOR complexes 1 (mTORC1) and 2 (mTORC2). However, recent discoveries have started to unravel the roles of DEPTOR in mTOR-independent responses. In the past few years, mTOR emerged as an important regulator of skeletal development, growth, and homeostasis; the dysregulation of its activity contributes to the development of several skeletal diseases, both chronic and genetic. Even more recently, several groups have reported on the relevance of DEPTOR in skeletal biology through its action on mTORdependent and mTOR-independent pathways. In this review, we summarize the current understanding of DEPTOR in skeletal development and disease.
eng
DEPTOR
mTOR
Skeleton
Bone
Cartilage
Proteína reguladora asociada a mTOR
Diana mecanicista del complejo 1 de la rapamicina
Esqueleto
Huesos
Cartílago
DEPTOR in Skeletal Development and Diseases
review article