2026-06-14T02:29:18Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/183562024-11-28T14:48:42Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Perez-Tejeiro, Jose Miguel author Csukasi, Fabiana author 2021-05-27 Discovered in 2009, the DEP-domain containing mTOR-interacting protein, DEPTOR, is a known regulator of the mechanistic target of rapamycin (mTOR), an evolutionarily conserved kinase that regulates diverse cellular processes in response to environmental stimuli. DEPTOR was originally identified as a negative regulator of mTOR complexes 1 (mTORC1) and 2 (mTORC2). However, recent discoveries have started to unravel the roles of DEPTOR in mTOR-independent responses. In the past few years, mTOR emerged as an important regulator of skeletal development, growth, and homeostasis; the dysregulation of its activity contributes to the development of several skeletal diseases, both chronic and genetic. Even more recently, several groups have reported on the relevance of DEPTOR in skeletal biology through its action on mTORdependent and mTOR-independent pathways. In this review, we summarize the current understanding of DEPTOR in skeletal development and disease. 10.3389/fgene.2021.667283 1664-8021 Frontiers in Genetics http://hdl.handle.net/10668/4091 34122519 http://hdl.handle.net/20.500.12105/18356 DEPTOR mTOR Skeleton Bone Cartilage Proteína reguladora asociada a mTOR Diana mecanicista del complejo 1 de la rapamicina Esqueleto Huesos Cartílago DEPTOR in Skeletal Development and Diseases