2026-08-29T15:33:38Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/183252024-11-28T14:45:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16962
Repisalud author Hernández, Domingo author Vázquez, Teresa author Alonso-Titos, Juana author León, Myriam author Caballero, Abelardo author Cobo, María Angeles author Sola, Eugenia author López, Verónica author Ruiz-Esteban, Pedro author Cruzado, Josep María author Sellarés, Joana author Moreso, Francesc author Manonelles, Anna author Torio, Alberto author Cabello, Mercedes author Delgado-Burgos, Juan author Casas, Cristina author Gutiérrez, Elena author Jironda, Cristina author Kanter, Julia author Serón, Daniel author Torres, Armando authoraffiliation [Hernández,D; Vázquez,T; Alonso-Titos,J; Sola,E; López,V; Ruiz-Esteban,P; Cabello,M; Delgado-Burgos,J; Casas,C; Gutiérrez,E; Jironda,C] Nephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), REDinREN (RD16/0009/0006), Málaga, Spain. [León,M] Pathology Department, Hospital Regional Universitario de Malaga, Instituto de Investigación Biomédica de Málaga (IBIMA), REDinREN (RD16/0009/0006), Málaga, Spain. [Caballero,A; Torio,A] Immunology Department, Hospital Regional Universitario de Málaga, University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), REDinREN (RD16/0009/0006), Málaga, Spain. [Cobo,MA; Torres,A] Nephrology Department, Instituto de Tecnologías Biomédicas-Universidad La Laguna, Hospital Universitario de Canarias, REDinREN (RD16/0009/0031), Tenerife, Spain. [Cruzado,JM; Manonelles,A;] Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, IDIBELL, REDinREN (RD16/0009/0003), Barcelona, Spain. [Sellarés,J; Moreso,F; Serón,D] Nephrology Department, Hospital Universitari Valld’Hebron, Universitat Autonoma, Barcelona, REDinREN (RD16/0009/0030), Barcelona, Spain. [Kanter,J] Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain. 2024-02-19T15:28:01Z 2024-02-19T15:28:01Z 2021-04-29 10.3390/jcm10091934 2077-0383 Journal of Clinical Medicine http://hdl.handle.net/10668/4370 33947168 http://hdl.handle.net/20.500.12105/18325 The impact of human leukocyte antigen (HLA)-mismatching on the early appearance of subclinical inflammation (SCI) in low-immunological-risk kidney transplant (KT) recipients is undetermined. We aimed to assess whether HLA-mismatching (A-B-C-DR-DQ) is a risk factor for early SCI. As part of a clinical trial (Clinicaltrials.gov, number NCT02284464), a total of 105 low-immunological-risk KT patients underwent a protocol biopsy on the third month post-KT. As a result, 54 presented SCI, showing a greater number of total HLA-mismatches (p = 0.008) and worse allograft function compared with the no inflammation group (48.5 ± 13.6 vs. 60 ± 23.4 mL/min; p = 0.003). Multiple logistic regression showed that the only risk factor associated with SCI was the total HLA-mismatch score (OR 1.32, 95%CI 1.06-1.64, p = 0.013) or class II HLA mismatching (OR 1.51; 95%CI 1.04-2.19, p = 0.032) after adjusting for confounder variables (recipient age, delayed graft function, transfusion prior KT, and tacrolimus levels). The ROC curve illustrated that the HLA mismatching of six antigens was the optimal value in terms of sensitivity and specificity for predicting the SCI. Finally, a significantly higher proportion of SCI was seen in patients with >6 vs. ≤6 HLA-mismatches (62.3 vs. 37.7%; p = 0.008). HLA compatibility is an independent risk factor associated with early SCI. Thus, transplant physicians should perhaps be more aware of HLA mismatching to reduce these early harmful lesions. eng Kidney transplantation HLA compatibility Subclinical inflammation Banff criteria Low-immunological risk Tacrolimus Delayed graft function ROC curve Biopsy Trasplante de riñón Funcionamiento retardado del injerto Curva ROC Biopsia Antígenos HLA Inflamación Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients research article