2026-06-14T05:05:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183242024-11-28T14:44:05Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Gerussi, Alessio
author
Natalini, Ambra
author
Antonangeli, Fabrizio
author
Mancuso, Clara
author
Agostinetto, Elisa
author
Barisani, Donatella
author
Di Rosa, Francesca
author
Andrade, Raul
author
Invernizzi, Pietro
authoraffiliation
[Gerussi,A; Mancuso,C; Barisani,D; Invernizzi,P] Centre for Autoimmune Liver Diseases, Division of Gastroenterology, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. [Gerussi,A; Mancuso,C; Barisani,D; Invernizzi,P] European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy. [Natalini,A; Antonangeli,F; Di Rosa,F] Institute of Molecular Biology and Pathology (IBPM), National Research Council of Italy (CNR), Rome, Italy. [Agostinetto,E] Academic Trials Promoting Team, Institut Jules Bordet, L’Universite’ Libre de Bruxelles (ULB), Brussels, Belgium. [Agostinetto,E] Medical Oncology and Hematology Unit, Humanitas Clinical and Research Center—IRCCS, Humanitas Cancer Center, Rozzano, Milan, Italy. [Agostinetto,E] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. [Andrade,R] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), UGC Aparato Digestivo, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain.
2024-02-19T15:28:00Z
2024-02-19T15:28:00Z
2021-04-27
10.3390/ijms22094557
1422-0067
International Journal of Molecular Sciences
http://hdl.handle.net/10668/3615
33925355
http://hdl.handle.net/20.500.12105/18324
Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.
eng
Inflammation
Autoimmune hepatitis
Autoimmunity
Genetics
Drug-induced liver injury
Inflammation
Hepatitis autoinmune
Autoimmunity
Genética
Enfermedad hepática inducida por sustancias y drogas
Inflamación
Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
review article