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00925njm 22002777a 4500 dc Gerussi, Alessio author Natalini, Ambra author Antonangeli, Fabrizio author Mancuso, Clara author Agostinetto, Elisa author Barisani, Donatella author Di Rosa, Francesca author Andrade, Raul author Invernizzi, Pietro author 2021-04-27 Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level. 10.3390/ijms22094557 1422-0067 International Journal of Molecular Sciences http://hdl.handle.net/10668/3615 33925355 http://hdl.handle.net/20.500.12105/18324 Inflammation Autoimmune hepatitis Autoimmunity Genetics Drug-induced liver injury Inflammation Hepatitis autoinmune Autoimmunity Genética Enfermedad hepática inducida por sustancias y drogas Inflamación Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models