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00925njm 22002777a 4500 dc Rodríguez-Capitán, Jorge author Sánchez-Pérez, Andrés author Ballesteros-Pradas, Sara author Millán-Gómez, Mercedes author Cardenal-Piris, Rosa author Oneto-Fernández, Manuel author Gutiérrez-Alonso, Lola author Rivera-López, Ricardo author Guisado-Rasco, Agustín author Cano-García, Macarena author Gutiérrez-Bedmar, Mario author Jiménez-Navarro, Manuel author 2021-04-25 The clinical significance of non-obstructive coronary artery disease is the subject of debate. Our objective was to evaluate the long-term cardiovascular prognosis associated with non-obstructive coronary artery disease in patients undergoing coronary angiography, and to conduct a stratification by sex, diabetes, and clinical indication. We designed a multi-centre retrospective longitudinal observational study of 3265 patients that were classified into three groups: normal coronary arteries (lesion 70%, 1196 patients). During a mean follow-up of 43 months, we evaluated a combined cardiovascular event: acute myocardial infarction, stroke, hospitalization for heart failure, or cardiovascular death. Multivariable-adjusted Cox proportional hazard models showed a worse prognosis in patients with non-obstructive coronary artery disease, in comparison with patients of normal coronary arteries group, in the total population (hazard ratio 1.72, 95% confidence interval 1.23-2.39; p for trend 10.3390/jcm10091863 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/17704 33923110 http://hdl.handle.net/20.500.12105/18322 acute coronary syndrome coronary angiography coronary artery disease diabetes mellitus sex Prognostic Implication of Non-Obstructive Coronary Lesions: A New Classification in Different Settings.