2026-08-29T09:16:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183192024-11-28T14:50:16Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Escriche-Escuder, Adrian
author
Trinidad-Fernández, Manuel
author
Pajares, Bella
author
Iglesias-Campos, Marcos
author
Alba, Emilio
author
Cuesta-Vargas, Antonio I.
author
Roldán-Jiménez, Cristina
authoraffiliation
[Escriche-Escuder,A; Trinidad-Fernández,M; Cuesta-Vargas,AI; Roldán-Jiménez,C] Department of Physiotherapy, University of Malaga, Málaga, Spain. [Escriche-Escuder,A; Trinidad-Fernández,M; Alba,E; Cuesta-Vargas,AI; Roldán-Jiménez,C] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Pajares,B; Iglesias-Campos,M; Alba,E] UGCI Oncológica Médica, Hospital Regional Universitario y Virgen de la Victoria, Málaga, Spain. [Cuesta-Vargas,AI] School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
2024-02-19T15:27:01Z
2024-02-19T15:27:01Z
2021-04-23
10.1038/s41598-021-88375-5
2045-2322
Scientific Reports
http://hdl.handle.net/10668/3786
33893370
http://hdl.handle.net/20.500.12105/18319
Changes in body composition and muscle dysfunction are common in metastatic breast cancer (MBC). Ultrasound imaging (US) offers reliable information about muscle and fat tissue architecture (thickness) and quality (echo-intensity). This study aimed to analyze the responsiveness of thickness and echo-intensity and its possible relationship with functional and patient reported-outcomes (PRO) in MBC patients after an exercise intervention. A prospective study was conducted in 2019. A 12-week exercise program was performed, including aerobic exercise and strength training. Measurements were made at baseline and after intervention. Thickness and echo-intensity were obtained from the quadriceps and biceps brachii and brachialis (BB). Mean differences were calculated using the T-Student parametric test for dependent samples of the differences in the means before and after the intervention (p = 0.05; 95% CI). Data from 13 MBC patients showed that some US muscle variables had significant differences after intervention. Best correlations were found between the quality of life questionnaire (QLQ-BR23) PRO and variables from BB muscle thickness in contraction (r = 0.61, p < 0.01), and Non-contraction (r = 0.55, p < 0.01). BB Muscle Non-contraction Thickness also explained 70% of QLQ-BR23 variance. In conclusion, muscle architecture biomarkers showed great responsiveness and are correlated with PRO after an exercise intervention in MBC patients.
eng
Breast
Metastatic
Neoplasms
Intervention
Biomarkers
Mama
Neoplasias
Biomarcadores
Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
research article