2026-08-29T09:17:16Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/183192024-11-28T14:50:16Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Escriche-Escuder, Adrian author Trinidad-Fernández, Manuel author Pajares, Bella author Iglesias-Campos, Marcos author Alba, Emilio author Cuesta-Vargas, Antonio I. author Roldán-Jiménez, Cristina author 2021-04-23 Changes in body composition and muscle dysfunction are common in metastatic breast cancer (MBC). Ultrasound imaging (US) offers reliable information about muscle and fat tissue architecture (thickness) and quality (echo-intensity). This study aimed to analyze the responsiveness of thickness and echo-intensity and its possible relationship with functional and patient reported-outcomes (PRO) in MBC patients after an exercise intervention. A prospective study was conducted in 2019. A 12-week exercise program was performed, including aerobic exercise and strength training. Measurements were made at baseline and after intervention. Thickness and echo-intensity were obtained from the quadriceps and biceps brachii and brachialis (BB). Mean differences were calculated using the T-Student parametric test for dependent samples of the differences in the means before and after the intervention (p = 0.05; 95% CI). Data from 13 MBC patients showed that some US muscle variables had significant differences after intervention. Best correlations were found between the quality of life questionnaire (QLQ-BR23) PRO and variables from BB muscle thickness in contraction (r = 0.61, p < 0.01), and Non-contraction (r = 0.55, p < 0.01). BB Muscle Non-contraction Thickness also explained 70% of QLQ-BR23 variance. In conclusion, muscle architecture biomarkers showed great responsiveness and are correlated with PRO after an exercise intervention in MBC patients. 10.1038/s41598-021-88375-5 2045-2322 Scientific Reports http://hdl.handle.net/10668/3786 33893370 http://hdl.handle.net/20.500.12105/18319 Breast Metastatic Neoplasms Intervention Biomarkers Mama Neoplasias Biomarcadores Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention