2026-04-29T04:52:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/183182024-09-21T22:03:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16969col_20.500.12105_16977col_20.500.12105_16982col_20.500.12105_16983col_20.500.12105_16989
Repisalud
author
Díaz-López, Andrés
author
Paz-Graniel, Indira
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Ruiz, Verónica
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Toledo, Estefanía
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Becerra-Tomás, Nerea
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Corella, Dolores
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Castañer, Olga
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Martínez, J Alfredo
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Alonso-Gómez, Ángel M
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Wärnberg, Julia
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Vioque, Jesús
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Romaguera, Dora
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López-Miranda, José
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Estruch, Ramon
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Tinahones, Francisco J
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Lapetra, José
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Serra-Majem, Luís
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Bueno-Cavanillas, Aurora
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Tur, Josep A
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Sánchez, Vicente Martín
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Pintó, Xavier
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Delgado-Rodríguez, Miguel
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Matía-Martín, Pilar
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Vidal, Josep
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Vázquez, Clotilde
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Daimiel, Lidia
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Villa, Tania Fernandez
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Ros, Emilio
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Eguaras, Sonia
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Babio, Nancy
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Sorlí, Jose V
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Goday, Albert
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Abete, Itziar
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Sierra, Lucas Tojal
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Barón-López, Francisco Javier
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Torres-Collado, Laura
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Morey, Marga
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Garcia-Rios, Antonio
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Casas, Rosa
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Bernal-López, María Rosa
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Santos-Lozano, José Manuel
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Navarro, Adela
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Gonzalez, Jose I
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Zomeño, María Dolores
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Zulet, Maria Angeles
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Luna, Jessica Vaquero
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Ramallal, Raul
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Fitó, Montse
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Salas-Salvadó, Jordi
2024-02-19T15:26:58Z
2024-02-19T15:26:58Z
2021-04-22
Diaz-Lopez A, Paz-Graniel I, Ruiz V, Toledo E, Becerra-Tomas N, Corella D, et al. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome. Sci Rep. 2021 Apr 22;11(1):8719.
http://hdl.handle.net/10668/17621https://hdl.handle.net/20.500.13003/19512
http://hdl.handle.net/20.500.12105/18318
33888780
10.1038/s41598-021-88028-7
2045-2322
Scientific reports
2-s2.0-85104626272
642742500072
L634870788
It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.
eng
Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome
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