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00925njm 22002777a 4500 dc Díaz-López, Andrés author Paz-Graniel, Indira author Ruiz, Verónica author Toledo, Estefanía author Becerra-Tomás, Nerea author Corella, Dolores author Castañer, Olga author Martínez, J Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramon author Tinahones, Francisco J author Lapetra, José author Serra-Majem, Luís author Bueno-Cavanillas, Aurora author Tur, Josep A author Sánchez, Vicente Martín author Pintó, Xavier author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Villa, Tania Fernandez author Ros, Emilio author Eguaras, Sonia author Babio, Nancy author Sorlí, Jose V author Goday, Albert author Abete, Itziar author Sierra, Lucas Tojal author Barón-López, Francisco Javier author Torres-Collado, Laura author Morey, Marga author Garcia-Rios, Antonio author Casas, Rosa author Bernal-López, María Rosa author Santos-Lozano, José Manuel author Navarro, Adela author Gonzalez, Jose I author Zomeño, María Dolores author Zulet, Maria Angeles author Luna, Jessica Vaquero author Ramallal, Raul author Fitó, Montse author Salas-Salvadó, Jordi author 2021-04-22 It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS. Diaz-Lopez A, Paz-Graniel I, Ruiz V, Toledo E, Becerra-Tomas N, Corella D, et al. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome. Sci Rep. 2021 Apr 22;11(1):8719. http://hdl.handle.net/10668/17621 https://hdl.handle.net/20.500.13003/19512 http://hdl.handle.net/20.500.12105/18318 33888780 10.1038/s41598-021-88028-7 2045-2322 Scientific reports 2-s2.0-85104626272 642742500072 L634870788 Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome