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00925njm 22002777a 4500 dc Marhuenda-Muñoz, María author Rinaldi de Alvarenga, José Fernando author Hernáez, Álvaro author Tresserra-Rimbau, Anna author Martínez-González, Miguel Ángel author Salas-Salvadó, Jordi author Corella, Dolores author Malcampo, Mireia author Martínez, José Alfredo author Alonso-Gómez, Ángel M author Wärnberg, Julia author Vioque, Jesús author Romaguera, Dora author López-Miranda, José author Estruch, Ramón author Tinahones, Francisco J author Lapetra, José author Serra-Majem, J Lluís author Bueno-Cavanillas, Aurora author Tur, Josep A author Sánchez, Vicente Martín author Pintó, Xavier author Delgado-Rodríguez, Miguel author Matía-Martín, Pilar author Vidal, Josep author Vázquez, Clotilde author Daimiel, Lidia author Ros, Emilio author Serra-Mir, Mercè author Vázquez-Ruiz, Zenaida author Nishi, Stephanie K author Sorlí, Jose V author Zomeño, María Dolores author Zulet, María Angeles author Vaquero-Luna, Jessica author Carabaño-Moral, Rosa author Notario-Barandiaran, Leyre author Morey, Marga author García-Ríos, Antonio author Gómez-Pérez, Ana M author Santos-Lozano, José Manuel author Buil-Cosiales, Pilar author Basora, Josep author Portolés, Olga author Schröder, Helmut author Abete, Itziar author Salaverria-Lete, Itziar author Toledo, Estefanía author Babio, Nancy author Fitó, Montse author Martínez-Huélamo, Miriam author Lamuela-Raventós, Rosa M author 2021-03-17 Carotenoids are pigments contained mainly in fruit and vegetables (F&V) that have beneficial effects on cardiometabolic health. Due to their lipophilic nature, co-ingestion of fat appears to increase their bioavailability via facilitating transfer to the aqueous micellar phase during digestion. However, the extent to which high fat intake may contribute to increased carotenoid plasma concentrations is still unclear. The objective was to examine the degree to which the consumption of different amounts of both carotenoid-rich foods and fats is associated with plasma carotenoid concentrations within a Mediterranean lifestyle context (subsample from the PREDIMED-Plus study baseline) where consumption of F&V and fat is high. The study population was categorized into four groups according to their self-reported consumption of F&V and fat. Carotenoids were extracted from plasma samples and analyzed by HPLC-UV-VIS-QqQ-MS/MS. Carotenoid systemic concentrations were greater in high consumers of F&V than in low consumers of these foods (+3.04 μmol/L (95% CI: 0.90, 5.17), p-value = 0.005), but circulating concentrations seemed to decrease when total fat intake was very high (-2.69 μmol/L (-5.54; 0.16), p-value = 0.064). High consumption of F&V is associated with greater systemic levels of total carotenoids, in particular when fat intake is low-to-moderate rather than very high. Marhuenda-Munoz M, de Alvarenga JFR, Hernaez A, Tresserra-Rimbau A, Martinez-Gonzalez MA, Salas-Salvado J, et al. High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma. Antioxidants. 2021 Mar;10(3):473. 2076-3921 http://hdl.handle.net/10668/17470 https://hdl.handle.net/20.500.13003/19622 http://hdl.handle.net/20.500.12105/18290 33802859 10.3390/antiox10030473 Antioxidants (Basel, Switzerland) 2-s2.0-85102598440 633302400001 Mediterranean diet PREDIMED-Plus study Bioactive compounds Dietary fats Liquid chromatography Mass spectrometry Matrix effect absorption Phytochemicals Plasma carotenoids High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma