2026-04-29T23:04:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/182852024-11-28T14:56:00Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16982
Repisalud
author
Moya-García, Aurelio A.
author
Pino-Ángeles, Almudena
author
Sánchez-Jiménez, Francisca
author
Urdiales, José Luis
author
Medina, Miguel Ángel
authoraffiliation
[Moya-García,AA; Urdiales,JL; Medina,MÁ] Departamento de Biología Molecular y Bioquímica, Universidad de Málaga, Málaga, Spain. [Moya-García,AA; Urdiales,JL; Medina,MÁ] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Pino-Ángeles,A] Unidad de Lípidos y Arteriosclerosis, Servicio de Medicina Interna, Hospital Universitario Reina Sofia, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, Córdoba, Spain. [Pino-Ángeles,A] Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain. [Sánchez-Jiménez,F; Urdiales,JL; Medina,MÁ] Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Málaga, Spain.
2024-02-19T15:26:28Z
2024-02-19T15:26:28Z
2021-03-11
10.3390/biom11030415
2218-273X
Biomolecules
http://hdl.handle.net/10668/4090
33799732
http://hdl.handle.net/20.500.12105/18285
Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. Its effects, sometimes contradictory, are mediated by at least four different G-protein coupled receptors, which expression and signalling pathways are tissue-specific. Histamine metabolism conforms a very complex network that connect many metabolic processes important for homeostasis, including nitrogen and energy metabolism. This review brings together and analyses the current information on the relationships of the "histamine system" with other important metabolic modules in human physiology, aiming to bridge current information gaps. In this regard, the molecular characterization of the role of histamine in the modulation of angiogenesis-mediated processes, such as cancer, makes a promising research field for future biomedical advances.
eng
Metabolic remodelling
Angiogenesis
Systems biology
Histamine
Cancer
Metabolism
Biología de sistemas
Histamina
Neoplasias
Homeostasis
Metabolismo
Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach
review article