2026-04-29T23:04:16Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/182852024-11-28T14:56:00Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16982

00925njm 22002777a 4500 dc Moya-García, Aurelio A. author Pino-Ángeles, Almudena author Sánchez-Jiménez, Francisca author Urdiales, José Luis author Medina, Miguel Ángel author 2021-03-11 Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. Its effects, sometimes contradictory, are mediated by at least four different G-protein coupled receptors, which expression and signalling pathways are tissue-specific. Histamine metabolism conforms a very complex network that connect many metabolic processes important for homeostasis, including nitrogen and energy metabolism. This review brings together and analyses the current information on the relationships of the "histamine system" with other important metabolic modules in human physiology, aiming to bridge current information gaps. In this regard, the molecular characterization of the role of histamine in the modulation of angiogenesis-mediated processes, such as cancer, makes a promising research field for future biomedical advances. 10.3390/biom11030415 2218-273X Biomolecules http://hdl.handle.net/10668/4090 33799732 http://hdl.handle.net/20.500.12105/18285 Metabolic remodelling Angiogenesis Systems biology Histamine Cancer Metabolism Biología de sistemas Histamina Neoplasias Homeostasis Metabolismo Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach