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00925njm 22002777a 4500 dc Trejo-Velasco, Blanca author Estevez-Loureiro, Rodrigo author Carrasco-Chinchilla, Fernando author Fernández-Vázquez, Felipe author Arzamendi, Dabit author Pan, Manuel author Pascual, Isaac author Nombela-Franco, Luis author Amat-Santos, Ignacio J author Freixa, Xavier author Hernández-Antolín, Rosa Ana author Trillo-Nouche, Ramiro author Andraka Ikazuriaga, Leire author López-Mínguez, José R author Sanmiguel Cervera, Dario author Sanchis, Juan author Diez-Gil, José Luis author Ruiz-Quevedo, Valeriano author Urbano-Carrillo, Cristóbal author Becerra-Muñoz, Víctor Manuel author Benito-González, Tomás author Li, Chi Hion author Mesa, Dolores author Avanzas, Pablo author Armijo, Germán author Serrador-Frutos, Ana María author Sanchis, Laura author Lobán, Covadonga Fernández-Golfín author Cid-Álvarez, Belén author Hernández-García, José María author Garrote-Coloma, Carmen author Fernández-Peregrina, Estefanía author Romero, Miguel author León Arguero, Víctor author Cruz-González, Ignacio author 2021-03-02 Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0.35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Mean age was 72.5 ± 11.5 years and 154 (67.5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP ≤ 0.35: Log-Rank 8.844, p = 0.003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection. 10.3390/jcm10051006 2077-0383 Journal of clinical medicine http://hdl.handle.net/10668/17460 33801311 http://hdl.handle.net/20.500.12105/18275 MitraClip mitral valve regurgitation mitral valve repair pulmonary hypertension right ventricular to pulmonary arterial coupling transthoracic echocardiography Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure.