2026-07-22T20:06:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/182582024-11-28T15:01:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Rico-Llanos, Gustavo A.
author
Borrego-González, Sara
author
Moncayo-Donoso, Miguelangel
author
Becerra, José
author
Visser, Rick
authoraffiliation
[Rico-Llanos,GA; Becerra,J; Visser,R] Department of Cell Biology, Genetics and Physiology, Faculty of Science, University of Málaga, IBIMA, Málaga, Spain. [Rico-Llanos,GA; Borrego-González,S; Moncayo-Donoso,M; Becerra,J; Visser,R] Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Málaga, Spain. [Rico-Llanos,GA; Becerra,J; Visser,R] Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Málaga, Spain. [Borrego-González,S] Materials Science Institute of Seville (ICMS), Joint CSIC-University of Seville Center, Seville, Spain. [Moncayo-Donoso,M] Tissue Engineering Group, Department of Pharmacy, Universidad Nacional de Colombia, Bogotá, Colombia. [Moncayo-Donoso,M] Biomimetics Laboratory, Biotechnology Institute, Universidad Nacional de Colombia, Bogotá, Colombia.
2024-02-19T15:25:06Z
2024-02-19T15:25:06Z
2021-02-17
10.3390/polym13040599
2073-4360
Polymers
http://hdl.handle.net/10668/4139
33671329
http://hdl.handle.net/20.500.12105/18258
Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration.
eng
Collagen
Bone tissue engineering
Scaffolds
Growth factors
Peptides
Colágeno
Huesos
Ingeniería de tejidos
Andamios del tejido
Péptidos y proteínas de señalización intercelular
Péptidos
Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering
review article