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oai:repisalud.isciii.es:20.500.12105/182582024-11-28T15:01:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Rico-Llanos, Gustavo A. author Borrego-González, Sara author Moncayo-Donoso, Miguelangel author Becerra, José author Visser, Rick author 2021-02-17 Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration. 10.3390/polym13040599 2073-4360 Polymers http://hdl.handle.net/10668/4139 33671329 http://hdl.handle.net/20.500.12105/18258 Collagen Bone tissue engineering Scaffolds Growth factors Peptides Colágeno Huesos Ingeniería de tejidos Andamios del tejido Péptidos y proteínas de señalización intercelular Péptidos Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering