2026-06-14T03:44:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/182502024-02-19T15:24:58Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Atzeni, Alessandro
author
Galié, Serena
author
Muralidharan, Jananee
author
Babio, Nancy
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Tinahones, Francisco José
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Vioque, Jesús
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Corella, Dolores
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Castañer, Olga
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Vidal, Josep
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Moreno-Indias, Isabel
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Torres-Collado, Laura
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Fernández-Carrión, Rebeca
author
Fitó, Montserrat
author
Olbeyra, Romina
author
Martínez-González, Miguel Angel
author
Bulló, Monica
author
Salas-Salvadó, Jordi
2024-02-19T15:24:58Z
2024-02-19T15:24:58Z
2021-02-10
10.3390/microorganisms9020346
2076-2607
Microorganisms
http://hdl.handle.net/10668/17169
33578731
http://hdl.handle.net/20.500.12105/18250
Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.
eng
16S sequencing
BMI
clinical trial
gut microbiota
obesity
weight loss
Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome.
research article