2026-06-14T03:52:19Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/182502024-02-19T15:24:58Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Atzeni, Alessandro author Galié, Serena author Muralidharan, Jananee author Babio, Nancy author Tinahones, Francisco José author Vioque, Jesús author Corella, Dolores author Castañer, Olga author Vidal, Josep author Moreno-Indias, Isabel author Torres-Collado, Laura author Fernández-Carrión, Rebeca author Fitó, Montserrat author Olbeyra, Romina author Martínez-González, Miguel Angel author Bulló, Monica author Salas-Salvadó, Jordi author 2021-02-10 Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation. 10.3390/microorganisms9020346 2076-2607 Microorganisms http://hdl.handle.net/10668/17169 33578731 http://hdl.handle.net/20.500.12105/18250 16S sequencing BMI clinical trial gut microbiota obesity weight loss Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome.