2026-08-05T15:43:09Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/182432024-09-21T20:56:04Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Fontalba-Romero, María I author Lopez-Enriquez, Soledad author Lago-Sampedro, Ana author García-Escobar, Eva author Pastori, Ricardo L author Domínguez-Bendala, Juan author Álvarez-Cubela, Silvia author Valdes, Sergio author Rojo, Gemma author Garcia-Fuentes, Eduardo author Labajos-Manzanares, María T author García-Serrano, Sara 2024-02-19T15:24:53Z 2024-02-19T15:24:53Z 2021-01-29 10.3390/nu13020436 2072-6643 Nutrients http://hdl.handle.net/10668/17155 33572759 http://hdl.handle.net/20.500.12105/18243 The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food. eng Mediterranean diet metabolic syndrome miRNA morbid obesity type 2 diabetes mellitus Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity. research article