2026-07-23T23:01:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/182322024-09-21T23:46:18Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Alvarenga, Marcos Papais
author
do Carmo, Luciana Ferreira
author
Vasconcelos, Claudia Cristina Ferreira
author
Alvarenga, Marina Papais
author
Alvarenga-Filho, Helcio
author
de Melo Bento, Cleonice Alves
author
Paiva, Carmen Lucia Antão
author
Leyva-Fernández, Laura
author
Fernández, Óscar
author
Papais-Alvarenga, Regina Maria
2024-02-19T15:24:44Z
2024-02-19T15:24:44Z
2021-01-08
10.1038/s41598-020-80535-3
2045-2322
Scientific reports
http://hdl.handle.net/10668/16944
33420337
http://hdl.handle.net/20.500.12105/18232
Neuromyelitis Optica and Multiple Sclerosis are idiopathic inflammatory demyelinating diseases of the central nervous system that currently are considered distinct autoimmune diseases, so differences in genetic susceptibility would be expected. This study aimed to investigate the HLA association with Neuromyelitis Optica by a systematic review with meta-analysis. The STROBE instrument guided research paper assessments. Thirteen papers published between 2009 and 2020 were eligible. 568 Neuromyelitis Optica patients, 41.4% Asians, 32.4% Latin Americans and 26.2% Europeans were analyzed. Only alleles of the DRB1 locus were genotyped in all studies. Neuromyelitis Optica patients have 2.46 more chances of having the DRB1*03 allelic group than controls. Ethnicity can influence genetic susceptibility. The main HLA association with Neuromyelitis Optica was the DRB1*03:01 allele in Western populations and with the DPB1*05:01 allele in Asia. Differences in the Multiple Sclerosis and Neuromyelitis Optica genetic susceptibility was confirmed in Afro descendants. The DRB1*03 allelic group associated with Neuromyelitis Optica has also been described in other systemic autoimmune diseases.
eng
Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis.
research article