2026-07-23T23:02:16Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/182322024-09-21T23:46:18Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Alvarenga, Marcos Papais author do Carmo, Luciana Ferreira author Vasconcelos, Claudia Cristina Ferreira author Alvarenga, Marina Papais author Alvarenga-Filho, Helcio author de Melo Bento, Cleonice Alves author Paiva, Carmen Lucia Antão author Leyva-Fernández, Laura author Fernández, Óscar author Papais-Alvarenga, Regina Maria author 2021-01-08 Neuromyelitis Optica and Multiple Sclerosis are idiopathic inflammatory demyelinating diseases of the central nervous system that currently are considered distinct autoimmune diseases, so differences in genetic susceptibility would be expected. This study aimed to investigate the HLA association with Neuromyelitis Optica by a systematic review with meta-analysis. The STROBE instrument guided research paper assessments. Thirteen papers published between 2009 and 2020 were eligible. 568 Neuromyelitis Optica patients, 41.4% Asians, 32.4% Latin Americans and 26.2% Europeans were analyzed. Only alleles of the DRB1 locus were genotyped in all studies. Neuromyelitis Optica patients have 2.46 more chances of having the DRB1*03 allelic group than controls. Ethnicity can influence genetic susceptibility. The main HLA association with Neuromyelitis Optica was the DRB1*03:01 allele in Western populations and with the DPB1*05:01 allele in Asia. Differences in the Multiple Sclerosis and Neuromyelitis Optica genetic susceptibility was confirmed in Afro descendants. The DRB1*03 allelic group associated with Neuromyelitis Optica has also been described in other systemic autoimmune diseases. 10.1038/s41598-020-80535-3 2045-2322 Scientific reports http://hdl.handle.net/10668/16944 33420337 http://hdl.handle.net/20.500.12105/18232 Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis.