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oai:repisalud.isciii.es:20.500.12105/182312024-09-17T10:56:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16983

00925njm 22002777a 4500 dc Galmes-Panades, Aina M author Konieczna, Jadwiga author Varela-Mato, Veronica author Abete, Itziar author Babio, Nancy author Fiol, Miquel author Antonio de Paz, José author Casas, Rosa author Olbeyra, Romina author Ruiz-Canela, Miguel author Palau-Galindo, Antoni author Castañer, Olga author Martín-García, Arturo author Estruch, Ramón author Vidal, Josep author Buil-Cosiales, Pilar author Wärnberg, Julia author Salas-Salvadó, Jordi author Martínez, J Alfredo author Romaguera, Dora author PREDIMED-Plus investigators author 2021-01-06 Background: The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditions remains unclear. We aimed to determine the prospective association between changes in PA and in SB with concurrent changes in body composition and to examine whether reallocating inactive time into different physical activity levels was associated with 12-month change to body composition in older adults. Methods: Longitudinal assessment nested in the PREDIMED-Plus trial. A subsample (n = 1564) of men and women (age 55-75 years) with overweight/obesity and metabolic syndrome from both arms of the PREDIMED-Plus trial was included in the present analysis. Participants were followed up at 6 and 12 months. Physical activity and SB were assessed using validated questionnaires. Out of 1564 participants, 388 wore an accelerometer to objectively measure inactive time and PA over a 7-day period. At each time point, participants' body composition was measured using dual-energy X-ray absorptiometry (DXA). Standard covariate-adjusted and isotemporal substitution modelling were applied to linear mixed-effects models. Results: Increasing 30 min of total PA and moderate-to-vigorous physical activity (MVPA) was associated with significant reductions in body fat (beta - 0.07% and - 0.08%) and visceral adipose tissue (VAT) (- 13.9 g, and - 15.6 g) at 12 months (all p values < 0.001). Reallocating 30 min of inactive time to MVPA was associated with reductions in body fat and VAT and with an increase in muscle mass and muscle-to-fat mass ratio (all p values < 0.001). Conclusions: At 12 months, increasing total PA and MVPA and reducing total SB and TV-viewing SB were associated with improved body composition in participants with overweight or obesity, and metabolic syndrome. This was also observed when substituting 30 min of inactive time with total PA, LPA and MVPA, with the greatest benefits observed with MVPA. Galmes-Panades AM, Konieczna J, Varela-Mato V, Abete I, Babio Nancy, Fiol M, et al. Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial. BMC Med. 2021 Jan 06;19(1):3. 10.1186/s12916-020-01847-9 1741-7015 BMC medicine http://hdl.handle.net/10668/16928 http://hdl.handle.net/20.500.13003/10442 33402165 L2007794042 2-s2.0-85098791895 http://hdl.handle.net/20.500.12105/18231 605202000001 Body composition Isotemporal substitution Physical activity Sedentary behaviour Visceral adipose tissue Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial