2026-07-21T15:39:21Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/182252024-11-28T15:08:37Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Segovia-Zafra, Antonio author Di Zeo-Sánchez, Daniel E. author López-Gómez, Carlos author Pérez-Valdés, Zeus author García-Fuentes, Eduardo author Andrade, Raúl J. author Lucena, M. Isabel author Villanueva-Paz, Marina authoraffiliation [Segovia-Zafra,A; Di Zeo-Sánchez,DE; Pérez-Valdés,Z; Andrade,RJ; Lucena,MI; Villanueva-Paz,M] Unidad de Gestión Clínica de Gastroenterología, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain. [Segovia-Zafra,A; Andrade,RJ; Lucena,MI] Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid , Spain. [Lucena.MI] Platform ISCIII de Ensayos Clínicos, UICEC-IBIMA, Málaga, Spain. [López-Gómez,C; García-Fuentes,E] Hospital Universitario Virgen de la Victoria, Málaga, Spain 2024-02-19T15:24:36Z 2024-02-19T15:24:36Z 2021 10.1016/j.apsb.2021.11.013 2211-3843 Acta Pharmaceutica Sinica B http://hdl.handle.net/10668/4120 35024301 http://hdl.handle.net/20.500.12105/18225 Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that prescription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health problem and a major cause of drug attrition. Given the lack of biomarkers for iDILI prediction, diagnosis and prognosis, searching new models to predict and study mechanisms of iDILI is necessary. One of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant iDILI. Thus, major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI patients. However, there are many gaps for explaining all the complexity of iDILI susceptibility and mechanisms. Therefore, there is a need to optimize preclinical human in vitro models to reduce the risk of iDILI during drug development. Here, the current experimental models and the future directions in iDILI modelling are thoroughly discussed, focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI models. We also comment about in silico approaches and the increasing relevance of patient-derived cellular models. eng Drug-induced liver injury Preclinical models Mechanisms Oxidative stress Mitochondrial damage Immune response Personalized medicine Enfermedad hepática inducida por sustancias y drogas Estrés oxidativo Inmunidad Medicina de precisión Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction review article