2026-07-21T08:48:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/182062024-11-29T23:02:44Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Sanchez-Vazquez, Raul
author
Guío-Carrión, Ana
author
Zapatero-Gaviria, Antonio
author
Martínez, Paula
author
Blasco, MA
funder
Botín Foundation
funder
Ministerio de Ciencia e Innovación (España)
funder
Comunidad de Madrid (España)
funder
World Cancer Research Fund International
funder
Consejo Nacional de Ciencia y Tecnología (México)
2024-02-15T09:25:29Z
2024-02-15T09:25:29Z
2021-01-11
Aging (Albany NY) . 2021;13(1):1-15
10.18632/aging.202463
1945-4589
Aging
33428591
http://hdl.handle.net/20.500.12105/18206
The incidence of severe manifestations of COVID-19 increases with age with older patients showing the highest mortality, suggesting that molecular pathways underlying aging contribute to the severity of COVID-19. One mechanism of aging is the progressive shortening of telomeres, which are protective structures at chromosome ends. Critically short telomeres impair the regenerative capacity of tissues and trigger loss of tissue homeostasis and disease. The SARS-CoV-2 virus infects many different cell types, forcing cell turn-over and regeneration to maintain tissue homeostasis. We hypothesize that presence of short telomeres in older patients limits the tissue response to SARS-CoV-2 infection. We measure telomere length in peripheral blood lymphocytes COVID-19 patients with ages between 29 and 85 years-old. We find that shorter telomeres are associated to increased severity of the disease. Individuals within the lower percentiles of telomere length and higher percentiles of short telomeres have higher risk of developing severe COVID-19 pathologies.
eng
Shorter telomere lengths in patients with severe COVID-19 disease.
journal article
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URL
https://repisalud.isciii.es/bitstreams/189c423a-bba2-40ac-b57a-89c5aa98374f/download
File
MD5
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application/pdf
Shortertelomerelengthsinpatients_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/d1060c1a-8823-4d83-840e-954d3fb92e10/download
File
MD5
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text/plain
Shortertelomerelengthsinpatients_2021.pdf.txt