2026-06-14T02:29:26Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/181952024-11-29T15:02:09Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Rodríguez-Seguel, Elisa
author
Villamayor, Laura
author
Arroyo, Noelia
author
De Andrés, Mónica P
author
Real Arribas, Francisco
author
Martín, Franz
author
Cano, David A
author
Rojas, Anabel
funder
Ministerio de Ciencia y Universidades (España)
2024-02-14T10:07:00Z
2024-02-14T10:07:00Z
2020-04
J Pathol . 2020 ;250(4):362-373
10.1002/path.5378
1096-9896
The Journal of pathology
31875961
http://hdl.handle.net/20.500.12105/18195
Pancreatic heterotopia is defined as pancreatic tissue outside its normal location in the body and anatomically separated from the pancreas. In this work we have analyzed the stomach glandular epithelium of Gata4 flox/flox ; Pdx1-Cre mice (Gata4KO mice). We found that Gata4KO glandular epithelium displays an atypical morphology similar to the cornified squamous epithelium and exhibits upregulation of forestomach markers. The developing gastric units fail to form properly, and the glandular epithelial cells do not express markers of gastric gland in the absence of GATA4. Of interest, the developing glands of the Gata4KO stomach express pancreatic cell markers. Furthermore, a mass of pancreatic tissue located in the subserosa of the Gata4KO stomach is observed at adult stages. Heterotopic pancreas found in Gata4-deficient mice contains all three pancreatic cell lineages: ductal, acinar, and endocrine. Moreover, Gata4 expression is downregulated in ectopic pancreatic tissue of some human biopsy samples. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
eng
Loss of GATA4 causes ectopic pancreas in the stomach.
journal article
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loosofgata4causesectopic_2020.pdf
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loosofgata4causesectopic_2020.pdf.txt