2026-04-29T07:35:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/181902024-11-29T14:00:47Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Yuan, Fangcheng author Hung, Rayjean J author Walsh, Naomi author Zhang, Han author Platz, Elizabeth A author Wheeler, William author Song, Lei author Arslan, Alan A author Beane Freeman, Laura E author Bracci, Paige author Canzian, Federico author Du, Mengmeng author Gallinger, Steven author Giles, Graham G author Goodman, Phyllis J author Kooperberg, Charles author Le Marchand, Loic author Neale, Rachel E author Rosendahl, Jonas author Scelo, Ghislaine author Shu, Xiao-Ou author Visvanathan, Kala author White, Emily author Zheng, Wei author Albanes, Demetrius author Amiano, Pilar author Andreotti, Gabriella author Babic, Ana author Bamlet, William R author Berndt, Sonja I author Brennan, Paul author Bueno-de-Mesquita, Bas author Buring, Julie E author Campbell, Peter T author Chanock, Stephen J author Fuchs, Charles S author Gaziano, J Michael author Goggins, Michael G author Hackert, Thilo author Hartge, Patricia author Hassan, Manal M author Holly, Elizabeth A author Hoover, Robert N author Katzke, Verena author Kirsten, Holger author Kurtz, Robert C author Lee, I-Min author Malats, Nuria author Milne, Roger L author Murphy, Neil author Ng, Kimmie author Oberg, Ann L author Porta, Miquel author Rabe, Kari G author Real Arribas, Francisco author Rothman, Nathaniel author Sesso, Howard D author Silverman, Debra T author Thompson, Ian M author Wactawski-Wende, Jean author Wang, Xiaoliang author Wentzensen, Nicolas author Wilkens, Lynne R author Yu, Herbert author Zeleniuch-Jacquotte, Anne author Shi, Jianxin author Duell, Eric J author Amundadottir, Laufey T author Li, Donghui author Petersen, Gloria M author Wolpin, Brian M author Risch, Harvey A author Yu, Kai author Klein, Alison P author Stolzenberg-Solomon, Rachael author 2020-09-15 Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (±500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. Combined genomic susceptibility regions for ulcerative colitis, Crohn disease, inflammatory bowel disease, and chronic pancreatitis were associated with PDAC at P values < 0.05 (0.0040, 0.0057, 0.011, and 3.4 × 10-6, respectively). After excluding the 20 PDAC susceptibility regions (±500 kb) previously identified by GWAS, the genomic regions for ulcerative colitis, Crohn disease, and inflammatory bowel disease remained associated with PDAC (P = 0.0029, 0.0057, and 0.0098, respectively). Genomic regions for celiac disease (P = 0.22) and primary sclerosing cholangitis (P = 0.078) were not associated with PDAC. Our results support the hypothesis that genomic regions surrounding variants associated with inflammatory intestinal diseases, particularly, ulcerative colitis, Crohn disease, inflammatory bowel disease, and chronic pancreatitis are associated with PDAC. SIGNIFICANCE: The joint effects of common variants in genomic regions containing susceptibility loci for inflammatory bowel disease and chronic pancreatitis are associated with PDAC and may provide insights to understanding pancreatic cancer etiology. Cancer Res . 2020 ;80(18):4004-4013 http://hdl.handle.net/20.500.12105/18190 32641412 10.1158/0008-5472.CAN-20-0447 1538-7445 Cancer research https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861352/ Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk.