2026-05-22T00:58:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/181812024-11-29T21:05:19Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Piñeiro-Hermida, Sergio
author
Autilio, Chiara
author
Martínez, Paula
author
Bosch, Fátima
author
Pérez-Gil, Jesús
author
Blasco, MA
author
MARTINEZ
funder
Fundación Banco Santander
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
funder
European Union (EU)
funder
RyPSE-CM Programme
2024-02-13T08:54:02Z
2024-02-13T08:54:02Z
2020-10-05
J Cell Biol . 2020 ;219(10):e202002120.
10.1083/jcb.202002120
1540-8140
The Journal of cell biology
32777016
http://hdl.handle.net/20.500.12105/18181
Short/dysfunctional telomeres are at the origin of idiopathic pulmonary fibrosis (IPF) in patients mutant for telomere maintenance genes. However, it remains unknown whether physiological aging leads to short telomeres in the lung, thus leading to IPF with aging. Here, we find that physiological aging in wild-type mice leads to telomere shortening and a reduced proliferative potential of alveolar type II cells and club cells, increased cellular senescence and DNA damage, increased fibroblast activation and collagen deposits, and impaired lung biophysics, suggestive of a fibrosis-like pathology. Treatment of both wild-type and telomerase-deficient mice with telomerase gene therapy prevented the onset of lung profibrotic pathologies. These findings suggest that short telomeres associated with physiological aging are at the origin of IPF and that a potential treatment for IPF based on telomerase activation would be of interest not only for patients with telomerase mutations but also for sporadic cases of IPF associated with physiological aging.
eng
Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging.
journal article
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URL
https://repisalud.isciii.es/bitstreams/1b26998d-a07a-4c7f-96c0-c8cbf8432258/download
File
MD5
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application/pdf
TelomerasetreatmentpreventslunG_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/6d104b1a-9471-452c-92d9-0c1d4f6e35bf/download
File
MD5
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text/plain
TelomerasetreatmentpreventslunG_2020.pdf.txt