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00925njm 22002777a 4500 dc Garcia-Clemente, Marta author de la Rosa, David author Máiz, Luis author Girón, Rosa author Blanco, Marina author Olveira, Casilda author Canton, Rafael author Martinez-García, Miguel Angel author 2020-11-24 Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of P. aeruginosa over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of "hypermutator P. aeruginosa strain". This phenomenon has been observed in people with bronchiectasis, CF, and the "exacerbator" COPD phenotype. From a clinical point of view, a chronic bronchial infection of P. aeruginosa has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of P. aeruginosa infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review. 10.3390/jcm9123800 2077-0383 Journal of Clinical Medicine http://hdl.handle.net/10668/3620 33255354 http://hdl.handle.net/20.500.12105/18161 Pseudomonas aeruginosa Bronchiectasis Cystic fibrosis COPD Asthma Chronic bronchial infection Bronquiectasia Fibrosis quística Enfermedad pulmonar obstructiva crónica Asma Bronquitis crónica Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases