2026-08-29T14:17:35Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/181492024-11-28T14:58:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Alba-Bernal, Alfonso author Lavado-Valenzuela, Rocío author Domínguez-Recio, María Emilia author Jiménez-Rodriguez, Begoña author Queipo-Ortuño, María Isabel author Alba, Emilio author Comino-Méndez, Iñaki authoraffiliation [Alba-Bernal,A; Lavado-Valenzuela,R; Domínguez-Recio,ME; Jiménez-Rodriguez,B; Queipo-Ortuño,MI; Alba,E; Comino-Méndez,I] Unidad de Gestion Clínica Intercentros de Oncología Medica, Hospitales Universitarios Regional y Virgen de la Victoria. The Biomedical Research Institute of Málaga (IBIMA-CIMES-UMA), Málaga, Spain. 2024-02-12T19:47:51Z 2024-02-12T19:47:51Z 2020-11-09 10.1016/j.ebiom.2020.103100 2352-3964 EBioMedicine http://hdl.handle.net/10668/3766 33161226 http://hdl.handle.net/20.500.12105/18149 Breast cancer is the most common cancer type in women worldwide and its early detection is crucial to curing the disease. Tissue biopsy, currently the method of choice to obtain tumour molecular information, is invasive and might be affected by tumour heterogeneity rendering it incapable to portray the complete molecular picture. Liquid biopsy permits to study disease features in a more comprehensive manner by sampling biofluids and extracting tumour components such as circulating-tumour DNA (ctDNA), circulating-tumour cells (CTCs), and/or circulating-tumour RNA (ctRNA) amongst others in a monitoring-compatible manner. In this review, we describe the recent progress in the utilization of the circulating tumour components using early breast cancer samples. We review the most important analytes and technologies employed for their study. eng Liquid biopsy Localized breast cancer Circulating-tumour DNA Circulating-tumour cells Circulating-tumour RNA Biopsia líquida Neoplasias de la mama ARN ADN Células ARN Circular Pacientes Challenges and achievements of liquid biopsy technologies employed in early breast cancer review article