2026-05-21T23:07:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/181342024-09-21T23:29:17Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16971col_20.500.12105_16983
Repisalud
author
García-Marchena, Nuria
author
Pizarro, Nieves
author
Pavón, Francisco-Javier
author
Martínez-Huélamo, Miriam
author
Flores-López, María
author
Requena-Ocaña, Nerea
author
Araos, Pedro
author
Silva-Peña, Daniel
author
Suárez, Juan
author
Santín, Luis J
author
de la Torre, Rafael
author
Rodríguez de Fonseca, Fernando
author
Serrano, Antonia
2024-02-12T19:47:36Z
2024-02-12T19:47:36Z
2020-10-13
10.1038/s41598-020-74155-0
2045-2322
Scientific reports
http://hdl.handle.net/10668/16413
33051508
http://hdl.handle.net/20.500.12105/18134
Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol addiction. A total of 55 abstinent alcohol use disorder (AUD) patients were compared with 34 age/sex/body mass index-matched controls. Concentrations of total LPA and 16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA species were quantified and correlated with neuroplasticity-associated growth factors including brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-2, and neurotrophin-3 (NT-3). AUD patients showed dysexecutive syndrome (22.4%) and memory impairment (32.6%). Total LPA, 16:0-LPA, 18:0-LPA and 18:1-LPA concentrations, were decreased in the AUD group compared to control group. Total LPA, 16:0-LPA, 18:2-LPA and 20:4-LPA concentrations were decreased in men compared to women. Frontal lobe functions correlated with plasma LPA species. Alcohol-cognitive impairments could be related with the deregulation of the LPA species, especially in 16:0-LPA, 18:1-LPA and 20:4-LPA. Concentrations of BDNF correlated with total LPA, 18:2-LPA and 20:4-LPA species. The relation between LPA species and BDNF is interesting in plasticity and neurogenesis functions, their involvement in AUD might serve as a biomarker of cognitive impairment.
eng
Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients.
research article