2026-07-21T11:29:18Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/181252024-11-28T15:48:04Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Ruiz-Moreno, Maria Isabel author Vilches-Perez, Alberto author Gallardo-Escribano, Cristina author Vargas-Candela, Antonio author Lopez-Carmona, Maria Dolores author Pérez-Belmonte, Luis Miguel author Ruiz-Moreno, Alejandro author Gomez-Huelgas, Ricardo author Bernal-Lopez, Maria Rosa authoraffiliation [Ruiz-Moreno,MI; Vargas-Candela,A; Lopez-Carmona,MD; Pérez-Belmonte,LM; Ruiz-Moreno,A; Gomez-Huelgas,R; Bernal-Lopez,MR] Internal Medicine Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), Regional University Hospital of Malaga, Malaga, Spain. [Vilches-Perez,A] Endocrinology and Nutrition Department, Instituto de Investigacion Biomedica de Malaga (IBIMA), University Hospital Virgen de la Victoria, Malaga, Spain. [Gallardo-Escribano,C] Clinical Analysis Department, Regional University Hospital of Malaga, Malaga, Spain. [Gomez-Huelgas,R] Medicine and Dermatology Department, University of Malaga, Malaga, Spain. [Gomez-Huelgas,R; Bernal-Lopez,MR] CIBER Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain. 2024-02-12T19:47:26Z 2024-02-12T19:47:26Z 2020-09-24 10.3390/ijerph17196995 1660-4601 1661-7827 International Journal of Environmental Research and Public Health http://hdl.handle.net/10668/4377 32987856 http://hdl.handle.net/20.500.12105/18125 Aim: Arteriosclerotic cardiovascular disease, one of the world’s leading causes of death, first manifests itself at an early age. The identification of children who may have increased cardiovascular risk in the future could be an important prevention strategy. Our aim was to assess the clinical, analytical, and dietary variables associated with arterial stiffness (AS), measured by carotid-femoral pulse wave velocity (cfPWV) in a prepubescent population with metabolically healthy obesity (MHO). Subjects and Methods: A cross-sectional study in prepubescent subjects with obesity who had ≤1 metabolic syndrome criteria (abdominal perimeter and blood pressure ≥90th percentile, triglycerides >150 mg/dL, HDL-cholesterol < 0.0001), BMI (r = 0.44; p < 0.0001), WHtR (r = 0.26; p = 0.02), fasting insulin levels (r = 0.28; p = 0.02), and insulin resistance (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index) (r = 0.25; p = 0.04). Multiple linear regression analysis identified BMI and HOMA-IR as independent parameters associated with cfPWV. Conclusions: Prepubescent children with obesity who were shown to be metabolically healthy presented with arterial stiffness, which is closely related to BMI and the state of insulin resistance. eng Arterial stiffness Carotid-femoral pulse wave velocity Prepubescent population Mediterranean diet Insulin resistance Metabolically healthy obesity Rigidez vascular Velocidad de la onda del pulso carotídeo-femoral Dieta mediterránea Resistencia a la insulina Obesidad metabólica benigna Metabolically Healthy Obesity: Presence of Arterial Stiffness in the Prepubescent Population research article