2026-04-29T04:09:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/181232024-11-28T14:43:27Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Gallardo-Escribano, Cristina
author
Buonaiuto, Verónica
author
Ruiz-Moreno, M. Isabel
author
Vargas-Candela, Antonio
author
Vilches-Perez, Alberto
author
Benitez-Porres, Javier
author
Romance-Garcia, Angel Ramon
author
Ruiz-Moreno, Alejandro
author
Gomez-Huelgas, Ricardo
author
Bernal-Lopez, M. Rosa
authoraffiliation
[Gallardo-Escribano,C] Clinical Analysis Department, Regional University Hospital of Malaga, Malaga, Spain. [Buonaiuto,V; Ruiz-Moreno,MI; Vargas-Candela,A; Ruiz-Moreno,A; Gomez-Huelgas,R; Bernal-Lopez,MR] Internal Medicine Department, Instituto de Investigación Biomédica de Malaga (IBIMA), Regional University Hospital of Malaga, Malaga, Spain. [Vilches-Perez,A] Endocrinology and Nutrition Department, Instituto de Investigación Biomédica de Malaga (IBIMA), University Hospital Virgen de la Victoria, Malaga, Spain. [Benitez-Porres,J] Department of Human Physiology, Physical Education and Sports. Faculty of Medicine, University of Malaga, Malaga, Spain. [Romance-Garcia,AR] Biodynamic and Body Composition Laboratory. Department of Didactics of Language, Arts, and Sport. Faculty of Education Science, University of Málaga, Malaga, Spain. [Gomez-Huelgas,R; Bernal-Lopez,MR] CIBER Patofisiología de la Obesidad y la Nutrición, Carlos III Health Institute, Madrid, Spain.
2024-02-12T19:47:25Z
2024-02-12T19:47:25Z
2020-09-23
http://hdl.handle.net/10668/4397
http://hdl.handle.net/20.500.12105/18123
32967728
10.1186/s13148-020-00935-0
1868-7083
Clinical Epigenetics
Background: Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or cardiovascular disease). MHO is closely related to lifestyle and environmental factors. Epigenetics has become an essential biological tool to analyze the link between obesity and metabolic status. The aim of this study was to determine whether MHO status is conditioned by the DNA methylation (DNAm) of several genes related to lipid metabolism (lipoprotein lipase, retinoid X receptor alpha, liver X receptor, stearoyl-CoA desaturase, sterol regulatory element binding factor 1), and inflammation (LEP) in peripheral blood mononuclear cells (PBMCs) from 131 prepubertal subjects with MHO phenotype after lifestyle modifications with personalized Mediterranean diet (MedDiet) combined with a physical activity (PA) program. Results: The DNAm of all studied genes were significantly modified in the population after 12 months of lifestyle modifications (MedDiet and PA). In addition, associations were found between the DNAm studies and BMI, homeostatic model assessment of insulin resistance, monounsaturated fatty acid and polyunsaturated fatty acid, moderate-vigorous PA, fat mass, and adherence to MedDiet. Conclusions: It was found that DNAm of genes related to lipid metabolism and inflammation are also present in childhood and that this methylation profile can be modified by interventions based on MedDiet and PA.
eng
Prepubertal population
Metabolically healthy obesity
Methylation
Lipid profile
Inflammatory profile
Lifestyle modification
Obesity
Obesidad metabólica benigna
Metilación
Obesidad
Niño
Niño preescolar
Inflamación
Lípidos
Estilo de vida saludable
Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification
research article