2026-06-14T02:28:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/181192024-11-28T14:45:36Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16958
Repisalud
author
Garcia-Leon, Juan Antonio
author
Caceres-Palomo, Laura
author
Sanchez-Mejias, Elisabeth
author
Mejias-Ortega, Marina
author
Nuñez-Diaz, Cristina
author
Fernandez-Valenzuela, Juan Jose
author
Sanchez-Varo, Raquel
author
Davila, Jose Carlos
author
Vitorica, Javier
author
Gutierrez, Antonia
authoraffiliation
[Garcia-Leon,JA; Caceres-Palomo,L; Sanchez-Mejias,E; Mejias-Ortega,M; Nuñez-Diaz,C; Fernandez-Valenzuela,JJ; Sanchez-Varo,R; Davila,JC; Gutierrez,A] Departamento Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA, Facultad de Ciencias, Universidad de Malaga, Malaga, Spain. [Garcia-Leon,JA; Caceres-Palomo,L; Sanchez-Mejias,E; Mejias-Ortega,M; Nuñez-Diaz,C; Fernandez-Valenzuela,JJ; Sanchez-Varo,R; Davila,JC; Vitorica,J; Gutierrez,A] Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Vitorica,J] Departamento Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Sevilla, Spain.
2024-02-12T19:47:20Z
2024-02-12T19:47:20Z
2020-09-18
10.3390/ijms21186867
1422-0067
International Journal of Molecular Sciences
http://hdl.handle.net/10668/3602
32962164
http://hdl.handle.net/20.500.12105/18119
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer's disease (AD). The pathology of AD is very complex and still not fully understood, since different neural cell types are involved in the disease. Although neuronal function is clearly deteriorated in AD patients, recently, an increasing number of evidences have pointed towards glial cell dysfunction as one of the main causative phenomena implicated in AD pathogenesis. The complex disease pathology together with the lack of reliable disease models have precluded the development of effective therapies able to counteract disease progression. The discovery and implementation of human pluripotent stem cell technology represents an important opportunity in this field, as this system allows the generation of patient-derived cells to be used for disease modeling and therapeutic target identification and as a platform to be employed in drug discovery programs. In this review, we discuss the current studies using human pluripotent stem cells focused on AD, providing convincing evidences that this system is an excellent opportunity to advance in the comprehension of AD pathology, which will be translated to the development of the still missing effective therapies.
eng
Human induced pluripotent stem cells (hiPSCs)
Disease modeling
Alzheimer’s disease
Microglia
Astrocytes
Oligodendrocytes
3D cultures
Brain organoids
Células madre pluripotentes inducidas
Enfermedad de Alzheimer
Microglía
Astrocitos
Oligodendroglía
Organoides
Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease
review article