2026-06-14T02:29:19Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/181192024-11-28T14:45:36Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16958

00925njm 22002777a 4500 dc Garcia-Leon, Juan Antonio author Caceres-Palomo, Laura author Sanchez-Mejias, Elisabeth author Mejias-Ortega, Marina author Nuñez-Diaz, Cristina author Fernandez-Valenzuela, Juan Jose author Sanchez-Varo, Raquel author Davila, Jose Carlos author Vitorica, Javier author Gutierrez, Antonia author 2020-09-18 Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer's disease (AD). The pathology of AD is very complex and still not fully understood, since different neural cell types are involved in the disease. Although neuronal function is clearly deteriorated in AD patients, recently, an increasing number of evidences have pointed towards glial cell dysfunction as one of the main causative phenomena implicated in AD pathogenesis. The complex disease pathology together with the lack of reliable disease models have precluded the development of effective therapies able to counteract disease progression. The discovery and implementation of human pluripotent stem cell technology represents an important opportunity in this field, as this system allows the generation of patient-derived cells to be used for disease modeling and therapeutic target identification and as a platform to be employed in drug discovery programs. In this review, we discuss the current studies using human pluripotent stem cells focused on AD, providing convincing evidences that this system is an excellent opportunity to advance in the comprehension of AD pathology, which will be translated to the development of the still missing effective therapies. 10.3390/ijms21186867 1422-0067 International Journal of Molecular Sciences http://hdl.handle.net/10668/3602 32962164 http://hdl.handle.net/20.500.12105/18119 Human induced pluripotent stem cells (hiPSCs) Disease modeling Alzheimer’s disease Microglia Astrocytes Oligodendrocytes 3D cultures Brain organoids Células madre pluripotentes inducidas Enfermedad de Alzheimer Microglía Astrocitos Oligodendroglía Organoides Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease